ArticlePLoS biology2010
Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery.
Article in PLoS biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- The role of the epidermal growth factor receptor (EGFR/ErbB1) in diabetic retinopathy and its therapeutic implications.Journal of translational medicine · 2026Review
- Differentiation signals from glia are fine-tuned to set neuronal numbers during development.eLife · 2022Article
- Photoreceptors generate neuronal diversity in their target field through a Hedgehog morphogen gradient ineLife · 2022Article
- Polarized epidermal growth factor secretion ensures robust vulval cell fate specification inDevelopment (Cambridge, England) · 2020Article
- Wrapping Glial Morphogenesis and Signaling Control the Timing and Pattern of Neuronal Differentiation in theJournal of experimental neuroscience · 2018Article
- Glia relay differentiation cues to coordinate neuronal development inScience (New York, N.Y.) · 2017Article
- THADA Regulates the Organismal Balance between Energy Storage and Heat Production.Developmental cell · 2017Article
- ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling.Journal of cell science · 2016Article
- Regulatory mechanisms of EGFR signalling during Drosophila eye development.Cellular and molecular life sciences : CMLS · 2016Review
- Maintenance of glia in the optic lamina is mediated by EGFR signaling by photoreceptors in adult Drosophila.PLoS genetics · 2015Article
- Communicating by touch--neurons are not alone.Trends in cell biology · 2014Review
- Regulation of branching dynamics by axon-intrinsic asymmetries in Tyrosine Kinase Receptor signaling.eLife · 2014Article
- Sequential axon-derived signals couple target survival and layer specificity in the Drosophila visual system.Neuron · 2014Article
- Endocytosis and signaling during development.Cold Spring Harbor perspectives in biology · 2014Article
- Cytonemes as specialized signaling filopodia.Development (Cambridge, England) · 2014Review
- Cytoplasmic capes are nuclear envelope intrusions that are enriched in endosomal proteins and depend upon βH-spectrin and Annexin B9.PloS one · 2014Article
- Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues.Journal of cell science · 2013Article
- Changes in Notch signaling coordinates maintenance and differentiation of the Drosophila larval optic lobe neuroepithelia.Developmental neurobiology · 2012Article
- Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors.PloS one · 2012Article
- Intracellular trafficking in Drosophila visual system development: a basis for pattern formation through simple mechanisms.Developmental neurobiology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The release of signaling molecules from neurons must be regulated, to accommodate their highly polarized structure. In the developing Drosophila visual system, photoreceptor neurons secrete the epidermal growth factor receptor ligand Spitz (Spi) from their cell bodies, as well as from their axonal termini. Here we show that subcellular localization of Rhomboid proteases, which process Spi, determines the site of Spi release from neurons. Endoplasmic reticulum (ER) localization of Rhomboid 3 is essential for its ability to promote Spi secretion from axons, but not from cell bodies. We demonstrate that the ER extends throughout photoreceptor axons, and show that this feature facilitates the trafficking of the Spi precursor, the ligand chaperone Star, and Rhomboid 3 to axonal termini. Following this trafficking step, secretion from the axons is regulated in a manner similar to secretion from cell bodies. These findings uncover a role for the ER in trafficking proteins from the neuronal cell body to axon terminus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.