ArticlePloS one2010
RNAi screen indicates widespread biological function for human natural antisense transcripts.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Natural antisense transcript Nat9a suppresses Scn9a (NaScientific reports · 2026Article
- SINEUP RNA rescues molecular phenotypes associated with CHD8 suppression in autism spectrum disorder model systems.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Recent insights into the functions and mechanisms of antisense RNA: emerging applications in cancer therapy and precision medicine.Frontiers in chemistry · 2023Review
- Novel cytoplasmic lncRNA IKBKBAS promotes lung adenocarcinoma metastasis by upregulating IKKβ and consequential activation of NF-κB signaling pathway.Cell death & disease · 2021Article
- Small Activating RNAs: Towards the Development of New Therapeutic Agents and Clinical Treatments.Cells · 2021Review
- Identification of Natural Antisense Transcripts in Mouse Brain and Their Association With Autism Spectrum Disorder Risk Genes.Frontiers in molecular neuroscience · 2021Article
- SINEUP Non-coding RNA Targeting GDNF Rescues Motor Deficits and Neurodegeneration in a Mouse Model of Parkinson's Disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- SINEUP non-coding RNAs rescue defective frataxin expression and activity in a cellular model of Friedreich's Ataxia.Nucleic acids research · 2019Article
- The Emerging Role of Major Regulatory RNAs in Cancer Control.Frontiers in oncology · 2019Review
- Natural antisense transcripts in diseases: From modes of action to targeted therapies.Wiley interdisciplinary reviews. RNA · 2018Review
- miR-498 promotes cell proliferation and inhibits cell apoptosis in retinoblastoma by directly targeting CCPG1.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Regulation of Adult Neurogenesis by Non-coding RNAs: Implications for Substance Use Disorders.Frontiers in neuroscience · 2018Review
- Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens.Molecular and cellular neurosciences · 2017Article
- Upregulating endogenous genes by an RNA-programmable artificial transactivator.Nucleic acids research · 2015Article
- The over-expression of aquaporin-1 alters erythroid gene expression in human erythroleukemia K562 cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Emerging epigenetic mechanisms of long non-coding RNAs.Neuroscience · 2014Review
- Regulation of the apolipoprotein gene cluster by a long noncoding RNA.Cell reports · 2014Article
- Targeting long non-coding RNA to therapeutically upregulate gene expression.Nature reviews. Drug discovery · 2013Review
- Conserved expression of natural antisense transcripts in mammals.BMC genomics · 2013Article
- Zinc-dependent regulation of the Adh1 antisense transcript in fission yeast.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
Abstract
Natural antisense transcripts represent a class of regulatory RNA molecules, which are characterized by their complementary sequence to another RNA transcript. Extensive sequencing efforts suggest that natural antisense transcripts are prevalent throughout the mammalian genome; however, their biological significance has not been well defined. We performed a loss-of-function RNA interference (RNAi) screen, which targeted 797 evolutionary conserved antisense transcripts, and found evidence for a regulatory role for a number of natural antisense transcripts. Specifically, we found that natural antisense transcripts for CCPG1 and RAPGEF3 may functionally disrupt signaling pathways and corresponding biological phenotypes, such as cell viability, either independently or in parallel with the corresponding sense transcript. Our results show that the large-scale siRNA screen can be applied to evaluate natural antisense transcript modulation of fundamental cellular events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.