ArticleInternational journal of nanomedicine2010
Release profile and stability evaluation of optimized chitosan/alginate nanoparticles as EGFR antisense vector.
Article in International journal of nanomedicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Selection of Cryoprotectant in Lyophilization of Progesterone-Loaded Stearic Acid Solid Lipid Nanoparticles.Pharmaceutics · 2020Article
- In vitro assessment of the antimicrobial efficacy of chitosan nanoparticles against major fish pathogens and their cytotoxicity to fish cell lines.Journal of fish diseases · 2020Article
- Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance.International journal of nanomedicine · 2017Article
- Anti-EGFR Agents: Current Status, Forecasts and Future Directions.Targeted oncology · 2016Review
- Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery.Polymers · 2016Review
- Thiolated chitosan nanoparticles as a delivery system for antisense therapy: evaluation against EGFR in T47D breast cancer cells.International journal of nanomedicine · 2011Article
- Preparation and characterization of a coacervate extended-release microparticulate delivery system for Lactobacillus rhamnosus.International journal of nanomedicine · 2011Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Chitosan/alginate nanoparticles which had been optimized in our previous study using two different N/P ratios were chosen and their ability to release epidermal growth factor receptor (EGFR) antisense was investigated. In addition, the stability of these nanoparticles in aqueous medium and after freeze-drying was investigated. In the case of both N/P ratios (5, 25), nanoparticles started releasing EGFR antisense as soon as they were exposed to the medium and the release lasted for approximately 50 hours. Nanoparticle size, shape, zeta potential, and release profile did not show any significant change after the freeze-drying process (followed by reswelling). The nanoparticles were reswellable again after freeze-drying in phosphate buffer with a pH of 7.4 over a period of six hours. Agarose gel electrophoresis of the nanoparticles with the two different N/P ratios showed that these nanoparticles could protect EGFR antisense molecules for six hours.
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Registered trials
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