ArticlePloS one2010
Synaptic plasticity in medial vestibular nucleus neurons: comparison with computational requirements of VOR adaptation.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 52 citations in OpenAlex.
- Learning Gravity: An Innately Constrained Bayesian Model of Human Vestibular Development.Audiology research · 2026Article
- Plastic Events of the Vestibular Nucleus: the Initiation of Central Vestibular Compensation.Molecular neurobiology · 2024Review
- Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Virtual Reality-Induced Modification of Vestibulo-Ocular Reflex Gain in Posturography Tests.Journal of clinical medicine · 2024Article
- De Novo Synthesized Estradiol: A Role in Modulating the Cerebellar Function.International journal of molecular sciences · 2020Review
- Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation.PLoS computational biology · 2019Article
- Cerebellar learning using perturbations.eLife · 2018Article
- Heading in the right direction: the importance of direction selectivity for cerebellar motor learning.The Journal of physiology · 2018Article
- The order of complexity of visuomotor learning.BMC neuroscience · 2017Article
- Impaired Motor Learning in a Disorder of the Inferior Olive: Is the Cerebellum Confused?Cerebellum (London, England) · 2017Article
- Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments.Scientific reports · 2016Article
- Unsupervised Learning in an Ensemble of Spiking Neural Networks Mediated by ITDP.PLoS computational biology · 2016Article
- Cerebellar-inspired algorithm for adaptive control of nonlinear dielectric elastomer-based artificial muscle.Journal of the Royal Society, Interface · 2016Article
- Article
- Modeling memory consolidation during posttraining periods in cerebellovestibular learning.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Implementation of linear sensory signaling via multiple coordinated mechanisms at central vestibular nerve synapses.Neuron · 2015Article
- Velocity-selective adaptation of the horizontal and cross-axis vestibulo-ocular reflex in the mouse.Experimental brain research · 2014Article
- Around LTD hypothesis in motor learning.Cerebellum (London, England) · 2014Review
- Signals and learning rules guiding oculomotor plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVestibulo-ocular reflex (VOR) gain adaptation, a longstanding experimental model of cerebellar learning, utilizes sites of plasticity in both cerebellar cortex and brainstem. However, the mechanisms by which the activity of cortical Purkinje cells may guide synaptic plasticity in brainstem vestibular neurons are unclear. Theoretical analyses indicate that vestibular plasticity should depend upon the correlation between Purkinje cell and vestibular afferent inputs, so that, in gain-down learning for example, increased cortical activity should induce long-term depression (LTD) at vestibular synapses. METHODOLOGY/PRINCIPAL
findingsHere we expressed this correlational learning rule in its simplest form, as an anti-Hebbian, heterosynaptic spike-timing dependent plasticity interaction between excitatory (vestibular) and inhibitory (floccular) inputs converging on medial vestibular nucleus (MVN) neurons (input-spike-timing dependent plasticity, iSTDP). To test this rule, we stimulated vestibular afferents to evoke EPSCs in rat MVN neurons in vitro. Control EPSC recordings were followed by an induction protocol where membrane hyperpolarizing pulses, mimicking IPSPs evoked by flocculus inputs, were paired with single vestibular nerve stimuli. A robust LTD developed at vestibular synapses when the afferent EPSPs coincided with membrane hyperpolarization, while EPSPs occurring before or after the simulated IPSPs induced no lasting change. Furthermore, the iSTDP rule also successfully predicted the effects of a complex protocol using EPSP trains designed to mimic classical conditioning.
conclusionsThese results, in strong support of theoretical predictions, suggest that the cerebellum alters the strength of vestibular synapses on MVN neurons through hetero-synaptic, anti-Hebbian iSTDP. Since the iSTDP rule does not depend on post-synaptic firing, it suggests a possible mechanism for VOR adaptation without compromising gaze-holding and VOR performance in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.