ArticlePLoS computational biology2010
Wide-field motion integration in fly VS cells: insights from an inverse approach.
Article in PLoS computational biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Molecular variability elicits a tunable switch with discrete neuromodulatory response phenotypes.Journal of computational neuroscience · 2016Article
- Cooperative integration and representation underlying bilateral network of fly motion-sensitive neurons.PloS one · 2014Article
- Proposed evolutionary changes in the role of myelin.Frontiers in neuroscience · 2013Article
- An inverse approach for elucidating dendritic function.Frontiers in computational neuroscience · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fly lobula plate tangential cells are known to perform wide-field motion integration. It is assumed that the shape of these neurons, and in particular the shape of the subclass of VS cells, is responsible for this type of computation. We employed an inverse approach to investigate the morphology-function relationship underlying wide-field motion integration in VS cells. In the inverse approach detailed, model neurons are optimized to perform a predefined computation: here, wide-field motion integration. We embedded the model neurons to be optimized in a biologically plausible model of fly motion detection to provide realistic inputs, and subsequently optimized model neuron with and without active conductances (g(Na), g(K), g(K(Na))) along their dendrites to perform this computation. We found that both passive and active optimized model neurons perform well as wide-field motion integrators. In addition, all optimized morphologies share the same blueprint as real VS cells. In addition, we also found a recurring blueprint for the distribution of g(K) and g(Na) in the active models. Moreover, we demonstrate how this morphology and distribution of conductances contribute to wide-field motion integration. As such, by using the inverse approach we can predict the still unknown distribution of g(K) and g(Na) and their role in motion integration in VS cells.
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