ReviewNature reviews. Cardiology2010
Induced pluripotent stem cells: developmental biology to regenerative medicine.
Review in Nature reviews. Cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 125 citations in OpenAlex.
- Phytosterols from Rosaceae Species as Dual Modulators of Neuroinflammation and Induced Pluripotency.Journal of molecular neuroscience : MN · 2025Article
- Maturation of human induced pluripotent stem cell-derived cardiomyocytes promoted by Brachyury priming.Scientific reports · 2025Article
- Reporter Alleles in hiPSCs: Visual Cues on Development and Disease.International journal of molecular sciences · 2024Review
- Engineering a conduction-consistent cardiac patch with rGO/PLCL electrospun nanofibrous membranes and human iPSC-derived cardiomyocytes.Frontiers in bioengineering and biotechnology · 2023Article
- Research Advances of Injectable Functional Hydrogel Materials in the Treatment of Myocardial Infarction.Gels (Basel, Switzerland) · 2022Review
- iPSC Therapy for Myocardial Infarction in Large Animal Models: Land of Hope and Dreams.Biomedicines · 2021Review
- The use of induced pluripotent stem cells in domestic animals: a narrative review.BMC veterinary research · 2020Review
- Applications of genetically engineered human pluripotent stem cell reporters in cardiac stem cell biology.Current opinion in biotechnology · 2018Review
- StemMapper: a curated gene expression database for stem cell lineage analysis.Nucleic acids research · 2018Article
- Cell population structure prior to bifurcation predicts efficiency of directed differentiation in human induced pluripotent cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Microscale Biomaterials with Bioinspired Complexity of Early Embryo Development and in the Ovary for Tissue Engineering and Regenerative Medicine.ACS biomaterials science & engineering · 2017Article
- Modeling structural and functional deficiencies of RBM20 familial dilated cardiomyopathy using human induced pluripotent stem cells.Human molecular genetics · 2016Article
- Induced Pluripotent Stem Cells as a new Strategy for Osteogenesis and Bone Regeneration.Stem cell reviews and reports · 2015Review
- Regenerative Therapy Prevents Heart Failure Progression in Dyssynchronous Nonischemic Narrow QRS Cardiomyopathy.Journal of the American Heart Association · 2015Article
- Real-time measurement of biomagnetic vector fields in functional syncytium using amorphous metal.Scientific reports · 2015Article
- Induced pluripotent stem cells for cardiovascular disease: from product-focused disease modeling to process-focused disease discovery.Regenerative medicine · 2015Review
- Effect of NELL1 gene overexpression in iPSC-MSCs seeded on calcium phosphate cement.Acta biomaterialia · 2014Article
- Stem cells: the pursuit of genomic stability.International journal of molecular sciences · 2014Review
- iPS cell-derived cardiogenicity is hindered by sustained integration of reprogramming transgenes.Circulation. Cardiovascular genetics · 2014Article
- Inhibition of DNA topoisomerase II selectively reduces the threat of tumorigenicity following induced pluripotent stem cell-based myocardial therapy.Stem cells and development · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear reprogramming of somatic cells with ectopic stemness factors to bioengineer pluripotent autologous stem cells signals a new era in regenerative medicine. The study of developmental biology has provided a roadmap for cardiac differentiation from embryonic tissue formation to adult heart muscle rejuvenation. Understanding the molecular mechanisms of stem-cell-derived cardiogenesis enables the reproducible generation, isolation, and monitoring of progenitors that have the capacity to recapitulate embryogenesis and differentiate into mature cardiac tissue. With the advent of induced pluripotent stem (iPS) cell technology, patient-specific stem cells provide a reference point to systematically decipher cardiogenic differentiation through discrete stages of development. Interrogation of iPS cells and their progeny from selected cohorts of patients is an innovative approach towards uncovering the molecular mechanisms of disease. Thus, the principles of cardiogenesis can now be applied to regenerative medicine in order to optimize personalized therapeutics, diagnostics, and discovery-based science for the development of novel clinical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.