ReviewJournal of the National Cancer Institute. Monographs2010
The impact of adding radiation treatment after breast conservation surgery for ductal carcinoma in situ of the breast.
Review in Journal of the National Cancer Institute. Monographs, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- DEGRO practical guidelines: radiotherapy of breast cancer II: radiotherapy of non-invasive neoplasia of the breast.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014Guideline
- Management of Low-Grade Ductal Carcinoma In Situ in a Supernumerary Breast: A Case Report.Cureus · 2025Article
- Three Different Primary Cancers, Including Breast, Esophagus, and Renal in a Single Patient: A Case Report.Clinical case reports · 2025Article
- Management of Ductal Carcinoma In Situ (DCIS) of the Breast: Present Approaches and Future Directions.Current oncology reports · 2019Review
- A population-based validation study of the DCIS Score predicting recurrence risk in individuals treated by breast-conserving surgery alone.Breast cancer research and treatment · 2015Article
- Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis.Cell division · 2013Article
- A multigene expression assay to predict local recurrence risk for ductal carcinoma in situ.Journal of the National Cancer Institute · 2013Article
- A multigene expression assay to predict local recurrence risk for ductal carcinoma in situ of the breast.Journal of the National Cancer Institute · 2013Article
- Basal cytokeratin as a potential marker of low risk of invasion in ductal carcinoma in situ.Clinics (Sao Paulo, Brazil) · 2013Article
- β1-Integrin via NF-κB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer.Breast cancer research : BCR · 2013Article
- Use of annual mammography among older women with ductal carcinoma in situ.Journal of general internal medicine · 2012Article
- Adjuvant tamoxifen reduces subsequent breast cancer in women with estrogen receptor-positive ductal carcinoma in situ: a study based on NSABP protocol B-24.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ductal carcinoma in situ (DCIS; intraductal carcinoma) is most commonly detected as suspicious microcalcifications on routine screening mammography in an asymptomatic woman. As most women with newly diagnosed DCIS are eligible for breast conservation treatment, a major decision for most women is whether or not to add radiation treatment after surgical excision (lumpectomy). In four prospective randomized clinical trials, the addition of radiation treatment after lumpectomy reduced the risk of local recurrence by approximately 50%, both for overall local recurrence and for the subset of invasive local recurrence. Nonetheless, efforts have continued to attempt to identify a subset of patients with favorable DCIS who are at sufficiently low risk of local recurrence that omitting radiation treatment is reasonable. Prospective and retrospective studies have demonstrated excellent long-term outcomes at 10 and 15 years after breast conservation treatment with radiation. Careful follow-up, including yearly surveillance mammography, after initial breast conservation treatment with radiation is warranted for the early detection of potentially salvageable local and local-regional recurrences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.