ArticleChemical senses2011
Conservation of indole responsive odorant receptors in mosquitoes reveals an ancient olfactory trait.
Article in Chemical senses, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 119 citations in OpenAlex.
- GravidInsects · 2026Article
- The olfactory neurobiology and chemical ecology of mosquito attraction to plant nutrient sources.Proceedings. Biological sciences · 2025Review
- The chemosensory world of mosquitoes: olfactory receptors and their role in blocking mosquito-borne disease transmission.Parasites & vectors · 2025Review
- Impact of elevated COScientific reports · 2025Article
- Attraction and aversion of noctuid moths to fermented food sources coordinated by olfactory receptors from distinct gene families.BMC biology · 2025Article
- Structural basis of odor sensing by insect heteromeric odorant receptors.Science (New York, N.Y.) · 2024Article
- Odorant receptors for floral- and plant-derived volatiles in the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae).PloS one · 2024Article
- Odor-evoked transcriptomics of Aedes aegypti mosquitoes.PloS one · 2023Article
- Single amino acid residue mediates reciprocal specificity in two mosquito odorant receptors.eLife · 2022Article
- Mosquito host-seeking diel rhythm and chemosensory gene expression is affected by age and Plasmodium stages.Scientific reports · 2022Article
- Odorant receptor orthologues in conifer-feeding beetles display conserved responses to ecologically relevant odours.Molecular ecology · 2022Article
- Screening for odorant receptor genes expressed in Aedes aegypti involved in host-seeking, blood-feeding and oviposition behaviors.Parasites & vectors · 2022Article
- Regulation of the antennal transcriptome of the dengue vector, Aedes aegypti, during the first gonotrophic cycle.BMC genomics · 2021Article
- Olfactory systems across mosquito species.Cell and tissue research · 2021Review
- Olfaction-Related Gene Expression in the Antennae of Female Mosquitoes From CommonFrontiers in physiology · 2021Article
- Optimization of Insect Odorant Receptor Trafficking and Functional Expression Via Transient Transfection in HEK293 Cells.Chemical senses · 2019Article
- Sex and age modulate antennal chemosensory-related genes linked to the onset of host seeking in the yellow-fever mosquito, Aedes aegypti.Scientific reports · 2019Article
- Role of gut microbiota in brain function and stress-related pathology.Bioscience of microbiota, food and health · 2019Review
- An odorant receptor from Anopheles sinensis in China is sensitive to oviposition attractants.Malaria journal · 2018Article
- Larval Diet Affects Male Pheromone Blend in a Laboratory Strain of the Medfly, Ceratitis capitata (Diptera: Tephritidae).Journal of chemical ecology · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Aedes aegypti and Anopheles gambiae are among the best-characterized mosquito species within the Culicinae and Anophelinae mosquito clades which diverged ∼150 million years ago. Despite this evolutionary distance, the olfactory systems of these mosquitoes exhibit similar morphological and physiological adaptations. Paradoxically, mosquito odorant receptors, which lie at the heart of chemosensory signal transduction pathways, belong to a large and highly divergent gene family. We have used 2 heterologous expression systems to investigate the functional characteristics of a highly conserved subset of Ors between Ae. aegypti and An. gambiae to investigate whether protein homology correlates with odorant-induced activation. We find that these receptors share similar odorant response profiles and that indole, a common and ecologically relevant olfactory cue, elicits strong responses from these homologous receptors. The identification of other highly conserved members of this Or clade from mosquito species of varying phylogenetic relatedness supports a model in which high sensitivity to indole represents an ancient ecological adaptation that has been preserved as a result of its life cycle importance. These results provide an understanding of how similarities and disparities among homologous OR proteins relate to olfactory function, which can lead to greater insights into the design of successful strategies for the control of mosquito-borne diseases.
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