ArticleThe Journal of biological chemistry2010
CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 63 citations in OpenAlex.
- Discovery and characterization of gene-by-environment and epistatic genetic effects in a vertebrate model.Cell genomics · 2026Article
- CCDC141 is a Connectin/Titin and Nesprin-1 binding protein that adapts cardiomyocytes to mechanical stress.Communications biology · 2025Article
- CDC20: a novel therapeutic target in cancer.American journal of translational research · 2023Review
- Exome sequencing of families from Ghana reveals known and candidate hearing impairment genes.Communications biology · 2022Article
- Genome-wide analysis identified novel susceptible genes of restless legs syndrome in migraineurs.The journal of headache and pain · 2022Article
- Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: BeyondBrain sciences · 2021Review
- Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty.NPJ genomic medicine · 2021Article
- ATF5 deficiency causes abnormal cortical development.Scientific reports · 2021Article
- Disrupted-in-schizophrenia 1 enhances the quality of circadian rhythm by stabilizing BMAL1.Translational psychiatry · 2021Article
- Centering and Shifting of Centrosomes in Cells.Cells · 2020Review
- Genetics and the heart rate response to exercise.Cellular and molecular life sciences : CMLS · 2019Review
- CAMDI interacts with the human memory-associated protein KIBRA and regulates AMPAR cell surface expression and cognition.PloS one · 2019Article
- Nasal Placode Development, GnRH Neuronal Migration and Kallmann Syndrome.Frontiers in cell and developmental biology · 2019Article
- An in-silico approach for discovery of microRNA-TF regulation of DISC1 interactome mediating neuronal migration.NPJ systems biology and applications · 2019Article
- Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.Biomarker research · 2018Article
- Genome-Wide Association Study of Psychosis Proneness in the Finnish Population.Schizophrenia bulletin · 2017Article
- Psychiatric behaviors associated with cytoskeletal defects in radial neuronal migration.Cellular and molecular life sciences : CMLS · 2017Review
- Discovery of novel heart rate-associated loci using the Exome Chip.Human molecular genetics · 2017Article
- CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism.The Journal of clinical endocrinology and metabolism · 2017Article
- Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor.EMBO reports · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Centrosomes play a crucial role in the directed migration of developing neurons. However, the underlying mechanism is poorly understood. This study has identified a novel disrupted in schizophrenia 1 (DISC1)-interacting protein, named CAMDI after coiled-coil protein associated with myosin II and DISC1, which translocates to the centrosome in a DISC1-dependent manner. Knockdown of CAMDI by shRNA revealed severely impaired radial migration with disoriented centrosomes. A yeast two-hybrid screen identified myosin II as a binding protein of CAMDI. CAMDI interacts preferentially with phosphomyosin II and induces an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Interestingly, one single nucleotide polymorphism of the CAMDI gene (R828W) is identified, and its gene product was found to reduce the binding ability to phosphomyosin II. Furthermore, mice with overexpression of R828W in neurons exhibit an impaired radial migration. Our findings indicate that CAMDI is required for radial migration probably through DISC1 and myosin II-mediated centrosome positioning during neuronal development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.