ArticleThe Journal of biological chemistry2010
Transcriptional regulation of selenoprotein W by MyoD during early skeletal muscle differentiation.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Effects of Selenium Supplementation on Growth Performance, Antioxidant and Metabolic Status in Fattening Lambs: A Systematic Review and Meta-Analysis.Biological trace element research · 2026Review
- Selenium-Biofortified Probiotics: A Synergistic Microbial-Nutritional Strategy Against Exercise-Induced Stress.Nutrients · 2026Review
- Selenium and Skeletal Muscle Health in Sports Nutrition.Nutrients · 2025Review
- Multiplexing light-inducible recombinases to control cell fate, Boolean logic, and cell patterning in mammalian cells.Science advances · 2025Article
- Biogenic Selenium Nanoparticles Synthesized by L. brevis 23017 Enhance Aluminum Adjuvanticity and Make Up for its Disadvantage in Mice.Biological trace element research · 2024Article
- Loss of SELENOW aggravates muscle loss with regulation of protein synthesis and the ubiquitin-proteasome system.Science advances · 2024Article
- Research progress on the biological regulatory mechanisms of selenium on skeletal muscle in broilers.Poultry science · 2024Review
- Compensatory Protection of Thioredoxin-Deficient Cells from Etoposide-Induced Cell Death by Selenoprotein W via Interaction with 14-3-3.International journal of molecular sciences · 2021Article
- Degradation of selenoprotein S and selenoprotein K through PPARγ-mediated ubiquitination is required for adipocyte differentiation.Cell death and differentiation · 2019Article
- Characterization of the promoter region of the bovine SIX1 gene: Roles of MyoD, PAX7, CREB and MyoG.Scientific reports · 2017Article
- MiR-23-TrxR1 as a novel molecular axis in skeletal muscle differentiation.Scientific reports · 2017Article
- Selenoprotein W redox-regulated Ca2+ channels correlate with selenium deficiency-induced muscles Ca2+ leak.Oncotarget · 2016Article
- Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.Scientific reports · 2016Article
- MyoD Is a Novel Activator of Porcine FIT1 Gene by Interacting with the Canonical E-Box Element during Myogenesis.International journal of molecular sciences · 2015Article
- ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression.Molecular and cellular biology · 2013Article
- Understanding selenoprotein function and regulation through the use of rodent models.Biochimica et biophysica acta · 2012Review
- Mapping and functional characterization of the murine smoothelin-like 1 promoter.BMC molecular biology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selenoprotein W (SelW) is expressed in various tissues, but it is especially high in the skeletal muscle of mammals. Such tissue-specific protein expression implies regulation by a tissue-specific factor. In this study, we investigated SelW expression during myogenic C2C12 cell differentiation using RT-PCR, quantitative PCR, and Western blot analysis. Both the protein and mRNA levels of SelW were increased during C2C12 cell differentiation, particularly during the early stage. Sequence analysis of the SelW promoter revealed four putative E-boxes, E1, E2, E3, and E4, which are known binding sites for MyoD, a myogenic transcriptional factor. Luciferase reporter assay showed that E1 and E4 were crucial for MyoD-dependent promoter activity. Using EMSA analysis, we observed that MyoD bound directly to E1 but not to E4, even though E4 mutation reduced SelW promoter activity in the luciferase reporter assay. Binding of MyoD to E1 was further investigated by ChIP assay. These results suggest that the SelW gene was activated by the binding of MyoD to a specific E-box during early skeletal muscle differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.