ArticleThorax2010
Patterns of fetal and infant growth are related to atopy and wheezing disorders at age 3 years.
Article in Thorax, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Preterm birth, infant weight gain, and childhood asthma risk: a meta-analysis of 147,000 European children.The Journal of allergy and clinical immunology · 2014Pooled it
- Trial
- ANRIL Promoter DNA Methylation: A Perinatal Marker for Later Adiposity.EBioMedicine · 2017Trial
- Associations of postnatal growth with asthma and atopy: the PROBIT Study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2013Trial
- Maternal asthma and lung function, childhood asthma and growth: the MAESTRO-Child study.ERJ open research · 2025Article
- Association of fetal growth trajectory with mitochondrial DNA copy number in the cord blood of newborns: evidence from a birth cohort.Frontiers in pediatrics · 2025Article
- Long-term pulmonary and neurodevelopmental impairment in a fetal growth restriction rabbit model.Scientific reports · 2023Article
- Are Babies Born Preterm High-Risk Asthma Candidates?Journal of clinical medicine · 2023Review
- Early-Life Weight Status and Risk of Childhood Asthma or Recurrent Wheeze in Preterm and Term Offspring.The journal of allergy and clinical immunology. In practice · 2023Article
- Association between household income levels and nutritional intake of allergic children under 6 years of age in Korea: 2019 Korea National Health and Nutrition Examination Survey and application of machine learning.Frontiers in public health · 2023Article
- Fetal thoracic circumference in mid-pregnancy and infant lung function.Pediatric pulmonology · 2023Article
- A nutritional supplement taken during preconception and pregnancy influences human milk macronutrients in women with overweight/obesity and gestational diabetes mellitus.Frontiers in nutrition · 2023Article
- Risk Factors Affecting Development and Persistence of Preschool Wheezing: Consensus Document of the Emilia-Romagna Asthma (ERA) Study Group.Journal of clinical medicine · 2022Article
- Early-life weight gain is associated with non-atopic asthma in childhood.The World Allergy Organization journal · 2022Article
- The Foetal Origins of Allergy and Potential Nutritional Interventions to Prevent Disease.Nutrients · 2022Review
- A nutritional supplement containing zinc during preconception and pregnancy increases human milk zinc concentrations.Frontiers in nutrition · 2022Article
- Prediction of fat-free mass in a multi-ethnic cohort of infants using bioelectrical impedance: Validation against the PEA POD.Frontiers in nutrition · 2022Article
- The effect of catch-up growth in the first year of life on later wheezing phenotypes.The European respiratory journal · 2020Article
- Identification of Critical Windows of Metabolic Programming of Metabolism and Lung Function in Male Offspring of Obese Dams.Clinical and translational science · 2020Article
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundLittle is known about whether patterns of early growth are associated with altered respiratory and immune development. This study relates prenatal and infant growth patterns to wheeze and atopy at age 3 years.
methodsBirth weight and length were measured in 1548 children born at term. Conditional fetal head and abdominal circumference growth velocities were calculated from antenatal ultrasound measurements. Conditional postnatal growth velocities were calculated from infant weight, length and adiposity data. Measures of size and conditional growth were related to parentally-reported infant and early childhood wheeze and to atopic status at age 3 years.
resultsThe risk of atopy increased by 46% per SD increase in abdominal circumference growth velocity from 11 to 19 weeks gestation but by 20% per SD decrease in abdominal growth velocity from 19 to 34 weeks (p=0.007 and p=0.011, respectively). The risk of atopic wheeze increased by 20% per SD decrease in 19-34-week abdominal growth (p=0.046). The risk of non-atopic wheeze increased by 10% per SD decrease in 11-19-week head circumference growth. Greater relative infant weight and adiposity gains were associated with both atopic and non-atopic wheeze.
conclusionsA rapid growth trajectory during 11-19 weeks gestation followed by late gestation growth faltering is associated with atopy, suggesting that influences affecting fetal growth may also alter immune development. A lower early fetal growth trajectory is associated with non-atopic wheeze, possibly reflecting an association with smaller airways. An association between postnatal adiposity gain and wheeze may partly reflect prenatal influences that cause fetal growth to falter but are then followed by postnatal adiposity gain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.