ArticleProceedings of the National Academy of Sciences of the United States of America2010
Hierarchical order of coexisting pre- and postsynaptic forms of long-term potentiation at synapses in amygdala.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 68 citations in OpenAlex.
- Acute ethanol inhibits asynchronous glutamate release from mouse basolateral amygdala synapses.Neuropharmacology · 2026Article
- Equal levels of pre- and postsynaptic potentiation produce unequal outcomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Advances in the Electrophysiological Recordings of Long-Term Potentiation.International journal of molecular sciences · 2023Review
- The role of hippocampal CaMKII in resilience to trauma-related psychopathology.Neurobiology of stress · 2022Article
- Article
- Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain.Nature communications · 2022Article
- Downregulation of kainate receptors regulating GABAergic transmission in amygdala after early life stress is associated with anxiety-like behavior in rodents.Translational psychiatry · 2021Article
- Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development.Nature communications · 2020Article
- Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala.eLife · 2020Article
- Upregulation of Anandamide Hydrolysis in the Basolateral Complex of Amygdala Reduces Fear Memory Expression and Indices of Stress and Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Diminishing fear: Optogenetic approach toward understanding neural circuits of fear control.Pharmacology, biochemistry, and behavior · 2018Review
- Long-Term Plasticity of Neurotransmitter Release: Emerging Mechanisms and Contributions to Brain Function and Disease.Annual review of neuroscience · 2018Review
- Non-canonical Mechanisms of Presynaptic Kainate Receptors Controlling Glutamate Release.Frontiers in molecular neuroscience · 2018Review
- Schizophrenia-Related Microdeletion Impairs Emotional Memory through MicroRNA-Dependent Disruption of Thalamic Inputs to the Amygdala.Cell reports · 2017Article
- Cortical kainate receptors and behavioral anxiety.Molecular brain · 2017Review
- SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Coexistence of Multiple Types of Synaptic Plasticity in Individual Hippocampal CA1 Pyramidal Neurons.Frontiers in synaptic neuroscience · 2017Article
- Acute and chronic ethanol exposure differentially regulate CB1 receptor function at glutamatergic synapses in the rat basolateral amygdala.Neuropharmacology · 2016Article
- Sound tuning of amygdala plasticity in auditory fear conditioning.Scientific reports · 2016Article
- Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain.Nature reviews. Neuroscience · 2016Review
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
Synaptic rules that may determine the interaction between coexisting forms of long-term potentiation (LTP) at glutamatergic central synapses remain unknown. Here, we show that two mechanistically distinct forms of LTP could be induced in thalamic input to the lateral nucleus of the amygdala (LA) with an identical presynaptic stimulation protocol, depending on the level of postsynaptic membrane polarization. One form of LTP, resulting from pairing of postsynaptic depolarization and low-frequency presynaptic stimulation, was both induced and expressed postsynaptically ("post-LTP"). The same stimulation in the absence of postsynaptic depolarization led to LTP, which was induced and expressed presynaptically ("pre-LTP"). The inducibility of coexisting pre- and postsynaptic forms of LTP at synapses in thalamic input followed a well-defined hierarchical order, such that pre-LTP was suppressed when post-LTP was induced. This interaction was mediated by activation of cannabinoid type 1 receptors by endogenous cannabinoids released in the lateral nucleus of the amygdala in response to activation of the type 1 metabotropic glutamate receptor. These results suggest a previously unknown mechanism by which the hierarchy of coexisting forms of long-term synaptic plasticity in the neural circuits of learned fear could be established, possibly reflecting the hierarchy of memories for the previously experienced fearful events according to their aversiveness level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.