ArticleProceedings of the National Academy of Sciences of the United States of America2010
Divergent and nonuniform gene expression patterns in mouse brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro.Developmental cell · 2025Article
- Unsupervised pattern identification in spatial gene expression atlas reveals mouse brain regions beyond established ontology.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Anatomical Diversity of the Adult Corticospinal Tract Revealed by Single-Cell Transcriptional Profiling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Merged magnetic resonance and light sheet microscopy of the whole mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Single Cell Transcriptome Analysis of Niemann-Pick Disease, Type C1 Cerebella.International journal of molecular sciences · 2020Article
- Location of the Cell Adhesion Molecule "Coxsackievirus and Adenovirus Receptor" in the Adult Mouse Brain.Frontiers in neuroanatomy · 2020Article
- Unsupervised machine learning using an imaging mass spectrometry dataset automatically reassembles grey and white matter.Scientific reports · 2019Article
- Fibrinogen Chains Intrinsic to the Brain.Frontiers in neuroscience · 2019Article
- Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.Neuron · 2018Article
- Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains.Analytical chemistry · 2018Article
- Divergence and inheritance of neocortical heterotopia in inbred and genetically-engineered mice.Neuroscience letters · 2017Article
- Possum-A Framework for Three-Dimensional Reconstruction of Brain Images from Serial Sections.Neuroinformatics · 2016Article
- Canonical genetic signatures of the adult human brain.Nature neuroscience · 2015Article
- Dynamic expression of tyrosine hydroxylase mRNA and protein in neurons of the striatum and amygdala of mice, and experimental evidence of their multiple embryonic origin.Brain structure & function · 2014Article
- Allen Brain Atlas: an integrated spatio-temporal portal for exploring the central nervous system.Nucleic acids research · 2013Article
- Article
- Differential functional constraints on the evolution of postsynaptic density proteins in neocortical laminae.PloS one · 2012Article
Corrections and comments
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Authors and funding
29 authors at 3 institutions in 1 country.
Funding
Abstract
Considerable progress has been made in understanding variations in gene sequence and expression level associated with phenotype, yet how genetic diversity translates into complex phenotypic differences remains poorly understood. Here, we examine the relationship between genetic background and spatial patterns of gene expression across seven strains of mice, providing the most extensive cellular-resolution comparative analysis of gene expression in the mammalian brain to date. Using comprehensive brainwide anatomic coverage (more than 200 brain regions), we applied in situ hybridization to analyze the spatial expression patterns of 49 genes encoding well-known pharmaceutical drug targets. Remarkably, over 50% of the genes examined showed interstrain expression variation. In addition, the variability was nonuniformly distributed across strain and neuroanatomic region, suggesting certain organizing principles. First, the degree of expression variance among strains mirrors genealogic relationships. Second, expression pattern differences were concentrated in higher-order brain regions such as the cortex and hippocampus. Divergence in gene expression patterns across the brain could contribute significantly to variations in behavior and responses to neuroactive drugs in laboratory mouse strains and may help to explain individual differences in human responsiveness to neuroactive drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.