ArticleProceedings of the National Academy of Sciences of the United States of America2010
Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 140 citations in OpenAlex.
- AgosOBP3 knockdown disrupts host plant preference in cotton-specialized Aphis gossypii.Pest management science · 2026Article
- A Safer Alternative Bio-Repellent: Targeting Mosquito Odorant-Binding Proteins with Catnip-Derived Nepetalactones fromInternational journal of molecular sciences · 2026Article
- In vitro larvicidal activity of selected azabenzimidazole and diarylquinoline derivatives against Anopheles gambiae and in silico mechanistic analysis.Molecular diversity · 2026Article
- Chemical Characterization, In Silico Investigations, In Vitro Evaluation of Allelopathic Potential and Insecticidal Activity of Laurus nobilis L. Essential Oil.Chemistry & biodiversity · 2026Article
- The Sequence Characteristics and Binding Properties of the Odorant-Binding Protein SvelOBP1 fromLife (Basel, Switzerland) · 2024Article
- Expression and purification of Drosophila OBP44a with the aids of LC-MS and NMR.Protein expression and purification · 2023Article
- Article
- Roles of insect odorant binding proteins in communication and xenobiotic adaptation.Frontiers in insect science · 2023Review
- Mosquito larvicidal activity of pyrrolidine-2,4-dione derivatives: An investigation againstSaudi journal of biological sciences · 2022Article
- Deltamethrin interacts with Culex quinquefasciatus odorant-binding protein: a novel potential resistance mechanism.Parasites & vectors · 2022Article
- Involvement of three chemosensory proteins in perception of host plant volatiles in the tea green leafhopper,Frontiers in physiology · 2022Article
- The 40-Year Mystery of Insect Odorant-Binding Proteins.Biomolecules · 2021Review
- Identification and Functional Analysis of SlitOBP11 FromFrontiers in physiology · 2021Article
- Article
- The Drosophila odorant-binding protein 28a is involved in the detection of the floral odour ß-ionone.Cellular and molecular life sciences : CMLS · 2020Article
- Functional Analysis of Two Odorant-Binding Proteins, MaltOBP9 and MaltOBP10, inFrontiers in physiology · 2020Article
- Article
- Chemosensory Gene Families in the Oligophagous Pear PestInsects · 2019Article
- Bioinformatic and biochemical analysis of the key binding sites of the pheromone binding protein ofPeerJ · 2019Article
- Deciphering the Odorant Binding, Activation, and Discrimination Mechanism of Dhelobp21 from Dastarus Helophoroides.Scientific reports · 2018Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Culex mosquitoes introduce the pathogens responsible for filariasis, West Nile virus, St. Louis encephalitis, and other diseases into humans. Currently, traps baited with oviposition semiochemicals play an important role in detection efforts and could provide an environmentally friendly approach to controlling their populations. The odorant binding proteins (OBPs) in the female's antenna play a crucial, if yet imperfectly understood, role in sensing oviposition cues. Here, we report the X-ray crystallography and NMR 3D structures of OBP1 for Culex quinquefasciatus (CquiOBP1) bound to an oviposition pheromone (5R,6S)-6-acetoxy-5-hexadecanolide (MOP). In both studies, CquiOBP1 had the same overall six-helix structure seen in other insect OBPs, but a detailed analysis revealed an important previously undescribed feature. There are two models for OBP-mediated signal transduction: (i) direct release of the pheromone from an internal binding pocket in a pH-dependent fashion and (ii) detection of a pheromone-induced conformational change in the OBP·pheromone complex. Although CquiOBP1 binds MOP in a pH-dependent fashion, it lacks the C terminus required for the pH-dependent release model. This study shows that CquiOBP binds MOP in an unprecedented fashion using both a small central cavity for the lactone head group and a long hydrophobic channel for its tail.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.