Trial reportCirculation2010
Acetaminophen increases blood pressure in patients with coronary artery disease.
Trial report in Circulation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 62 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease
A Randomized, Open-label Study Investigating the Effect of Bilateral Renal Artery Sympathetic Denervation by Catheter-based Radiofrequency Ablation on Blood Pressure and Disease Progression in Autosomal Dominant Polycystic Kidney Disease
Who cites it
62 citing papers in PubMed, 5 syntheses or guidelines pooled it, 174 citations in OpenAlex.
- Urinary Acetaminophen Metabolites and Clinical Outcomes in Extremely Premature Infants.American journal of perinatology · 2025Pooled it
- Cardiovascular risk associated with high sodium-containing drugs: A systematic review.PloS one · 2017Pooled it
- Clinical management of drug-induced hypertension: 2013 Practical Recommendations of the Italian Society of Hypertension (SIIA).High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2014Guideline
- A systematic review of the effect of paracetamol on blood pressure in hypertensive and non-hypertensive subjects.British journal of clinical pharmacology · 2013Pooled it
- Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis: integrating systematic literature research and expert opinion of a broad panel of rheumatologists in the 3e Initiative.Rheumatology (Oxford, England) · 2012Pooled it
- Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement) Trial.European heart journal · 2017Trial
- Usefulness of ambulatory blood pressure monitoring to assess the melanocortin receptor agonist bremelanotide.Journal of hypertension · 2017Trial
- SAVE-AMD: Safety of VEGF Inhibitors in Age-Related Macular Degeneration.Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · 2017Trial
- Evaluation of blood pressure and heart rate in patients with hypertension who received tapentadol extended release for chronic pain: a post hoc, pooled data analysis.Clinical drug investigation · 2014Trial
- A randomized, placebo-controlled trial to determine the course of aminotransferase elevation during prolonged acetaminophen administration.BMC pharmacology & toxicology · 2014Trial
- Article
- Antimicrobial potentials and challenges of paracetamol: A comprehensive reassessment based on database reports.Pharmaceutical science advances · 2025Review
- Effects of a novel acetaminophen analog on cardiorespiratory compensatory responses and survival in a male rat model of traumatic hemorrhage.Physiological reports · 2025Article
- Vascular function in patients with advanced heart failure and continuous-flow or pulsatile ventricular assist devices.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Article
- Vascular Endothelial Effects of Sacubitril/Valsartan in Heart Failure With Reduced Ejection Fraction: Randomized Controlled Trial.JACC. Advances · 2024Article
- Article
- Balancing the evidence: An update on analgesic use in rheumatic and musculoskeletal diseases.Frontiers in drug safety and regulation · 2023Review
- The Effects of Pain and Analgesic Medications on Blood Pressure.Current hypertension reports · 2022Review
- Acetaminophen Exacerbates Hypertension: A #NephJC Editorial on PATH-BP.Kidney medicine · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBecause traditional nonsteroidal antiinflammatory drugs are associated with increased risk for acute cardiovascular events, current guidelines recommend acetaminophen as the first-line analgesic of choice on the assumption of its greater cardiovascular safety. Data from randomized clinical trials prospectively addressing cardiovascular safety of acetaminophen, however, are still lacking, particularly in patients at increased cardiovascular risk. Hence, the aim of this study was to evaluate the safety of acetaminophen in patients with coronary artery disease. METHODS AND
resultsThe 33 patients with coronary artery disease included in this randomized, double-blind, placebo-controlled, crossover study received acetaminophen (1 g TID) on top of standard cardiovascular therapy for 2 weeks. Ambulatory blood pressure, heart rate, endothelium-dependent and -independent vasodilatation, platelet function, endothelial progenitor cells, markers of the renin-angiotensin system, inflammation, and oxidative stress were determined at baseline and after each treatment period. Treatment with acetaminophen resulted in a significant increase in mean systolic (from 122.4±11.9 to 125.3±12.0 mm Hg P=0.02 versus placebo) and diastolic (from 73.2±6.9 to 75.4±7.9 mm Hg P=0.02 versus placebo) ambulatory blood pressures. On the other hand, heart rate, endothelial function, early endothelial progenitor cells, and platelet function did not change.
conclusionsThis study demonstrates for the first time that acetaminophen induces a significant increase in ambulatory blood pressure in patients with coronary artery disease. Thus, the use of acetaminophen should be evaluated as rigorously as traditional nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors, particularly in patients at increased cardiovascular risk. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00534651.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.