Evidence map›Paper›PMID 20955937›Full record

ReviewNeuron2010

Genetic advances in the study of speech and language disorders.

D F Newbury, A P Monaco

Open access · hybridAbstract readReview
In one paragraph

Review in Neuron, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
22.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 218 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Investigating Sequence Variations inClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Differences in Cortical Surface Area in Developmental Language Disorder.Neurobiology of language (Cambridge, Mass.) · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Malocclusion in children with speech sound disorders and motor speech involvement: a cross-sectional clinical study in Swedish children.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022
    Article
  16. Article
  17. Plasticity of the language system in children and adults.Handbook of clinical neurology · 2022
    Review
  18. Article
  19. Dopamine, vocalization, and astrocytes.Brain and language · 2021
    Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

D F NewburyWellcome Trust Centre for Human Genetics, Headington, Oxford, UK. dianne@well.ox.ac.uk
A P Monaco
Centre for Human Genetics · GB

Funding

Wellcome Trust 075491Wellcome Trust 076566
6 · The paper itself

Abstract

Developmental speech and language disorders cover a wide range of childhood conditions with overlapping but heterogeneous phenotypes and underlying etiologies. This characteristic heterogeneity hinders accurate diagnosis, can complicate treatment strategies, and causes difficulties in the identification of causal factors. Nonetheless, over the last decade, genetic variants have been identified that may predispose certain individuals to different aspects of speech and language difficulties. In this review, we summarize advances in the genetic investigation of stuttering, speech-sound disorder (SSD), specific language impairment (SLI), and developmental verbal dyspraxia (DVD). We discuss how the identification and study of specific genes and pathways, including FOXP2, CNTNAP2, ATP2C2, CMIP, and lysosomal enzymes, may advance our understanding of the etiology of speech and language disorders and enable us to better understand the relationships between the different forms of impairment across the spectrum.

Indexed as

Forkhead Transcription FactorsGenetic TestingGenetic VariationHumansLanguage DisordersMembrane ProteinsNerve Tissue ProteinsRepressor ProteinsSpeech DisordersCNTNAP2 protein, humanForkhead Transcription FactorsFOXP1 protein, humanFOXP2 protein, humanMembrane ProteinsNerve Tissue ProteinsRepressor Proteins

Identifiers

PMID20955937
PMCPMC2977079
OpenAlexW2032148110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.