Evidence map›Paper›PMID 20955933›Full record

ReviewNeuron2010

The genetics of child psychiatric disorders: focus on autism and Tourette syndrome.

Matthew W State

Abstract readReview
In one paragraph

Review in Neuron, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Distribution of disease-associated copy number variants across distinct disorders of cognitive development.Journal of the American Academy of Child and Adolescent Psychiatry · 2013
    Pooled it
  4. STX209 (arbaclofen) for autism spectrum disorders: an 8-week open-label study.Journal of autism and developmental disorders · 2014
    Trial
  5. Article
  6. Review
  7. Article
  8. Genes · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Proband and Familial Autoimmune Diseases Are Associated With Proband Diagnosis of Autism Spectrum Disorders.Journal of the American Academy of Child and Adolescent Psychiatry · 2019
    Article
  16. Article
  17. AutismKB 2.0: a knowledgebase for the genetic evidence of autism spectrum disorder.Database : the journal of biological databases and curation · 2018
    Article
  18. Article
  19. Review
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Matthew W StateDepartment of Child Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA. matthew.state@yale.edu

Funding

Genomic Profiling and Functional Mutation Analysis in Autism Spectrum DisordersRC2MH089956 · NIMH · YALE UNIVERSITY · PI GIRALDEZ, ANTONIO J, STATE, MATTHEW W. · 2009 to 2010
$2.2M
The Role of SLITRK1 in Tourette and Related DisordersR01NS056276 · NINDS · YALE UNIVERSITY · PI STATE, MATTHEW W. · 2006 to 2010
$2.1M
2/8-Collaborative genomic studies of Tourette DisorderR01MH092289 · NIMH · YALE UNIVERSITY · PI STATE, MATTHEW W. · 2011 to 2013
$898k
NIMH NIH HHS R01 MH092289NIMH NIH HHS RC2 MH089956NINDS NIH HHS R01 NS056276
6 · The paper itself

Abstract

Investigations into the genetics of child psychiatric disorders have finally begun to shed light on molecular and cellular mechanisms of psychopathology. The first strains of success in this notoriously difficult area of inquiry are the result of an increasingly sophisticated appreciation of the allelic architecture of common neuropsychiatric and neurodevelopmental disorders, the consolidation of large patient cohorts now beginning to reach sufficient size to power reliable studies, the emergence of genomic tools enabling comprehensive investigations of rare as well as common genetic variation, and advances in developmental neuroscience that are fueling the rapid translation of genetic findings.

Indexed as

Child PsychiatryGenetic Predisposition to DiseaseAutistic DisorderChildGenetic VariationGenome-Wide Association StudyHumansTourette Syndrome

Identifiers

PMID20955933
PMCPMC3292208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.