Evidence map›Paper›PMID 20955923›Full record

ArticleNeuron2010

Healing genes in the nervous system.

Xandra O Breakefield, Miguel Sena-Esteves

Abstract read
In one paragraph

Article in Neuron, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xandra O BreakefieldDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. breakefield@hms.harvard.edu
Miguel Sena-Esteves

Funding

The role of microvesicles in giloma virotherapyP01CA069246 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAREST, ALAIN · 1996 to 2021
$30.9M
Vector Query and Therapy For TSC and NF2 LesionsP01NS024279 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI KWIATKOWSKI, DAVID J. · 1987 to 2012
$14.7M
Torsin Function in DrosiphilaP50NS037409 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS · 2008 to 2013
$9.2M
Torsin Function in DrosiphilaP01NS037409 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI STANDAERT, DAVID G · 1999 to 2007
$8.5M
AAV-mediated gene therapy for GM2-gangliodosesU01NS064096 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ESTEVES, MIGUEL S · 2009 to 2012
$3.5M
Gene Therapy for Neurodegenerative Lysosomal Storage DiseasesR01HD060576 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ESTEVES, MIGUEL S, MARTIN, DOUGLAS R · 2010 to 2013
$2.0M
Development of CNS-targeted AAV vectorsR01NS066310 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ESTEVES, MIGUEL S · 2009 to 2012
$1.3M
NCI NIH HHS CA069246NCI NIH HHS P01 CA069246NICHD NIH HHS R01 HD060576NICHD NIH HHS R01HD060576NINDS NIH HHS NS037409NINDS NIH HHS NS24279NINDS NIH HHS P01 NS024279NINDS NIH HHS P01 NS037409NINDS NIH HHS R01 NS066310NINDS NIH HHS R01NS066310NINDS NIH HHS U01 NS064096NINDS NIH HHS U01NS064096
6 · The paper itself

Abstract

The evolution of gene therapy has led to the development of promising new therapeutic approaches. This NeuroView will introduce the variety of delivery vehicles currently available for gene therapy, a range of preclinical strategies for tackling major diseases of the nervous system, the clinical limitations, and ethical considerations.

Indexed as

Nervous System DiseasesAnimalsGenetic TherapyGene Transfer TechniquesHumansNervous System

Identifiers

PMID20955923
PMCPMC3076203

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.