ReviewInternational journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2011
Childhood onset schizophrenia: support for a progressive neurodevelopmental disorder.
Review in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 4 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Pooled it
- Clinical features and comorbidity in very early-onset schizophrenia: a systematic review.Frontiers in psychiatry · 2023Pooled it
- Psychological interventions for psychosis in adolescents.The Cochrane database of systematic reviews · 2020Pooled it
- Atypical antipsychotics for psychosis in adolescents.The Cochrane database of systematic reviews · 2013Pooled it
- Dynamic network reconfigurations during task engagement following resting state in adolescent onset schizophrenia.bioRxiv : the preprint server for biology · 2026Article
- Glutathione deficiency in the early postnatal developmental period as a neurodevelopmental animal model of schizophrenia.Pharmacological reports : PR · 2026Review
- Childhood-Onset Psychosis: A large UK case series.European child & adolescent psychiatry · 2026Article
- Article
- Neurocognitive dysfunctions in childhood-onset schizophrenia: A systematic review.Schizophrenia research. Cognition · 2025Review
- Energy of Functional Brain States Correlates With Cognition in Adolescent-Onset Schizophrenia and Healthy Persons.Human brain mapping · 2025Article
- A self-supervised learning framework for discovering cortical folding patterns under genetic influence: Application to the Anterior Cingulate Cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The effect of phencyclidine-mediated blockade of NMDA receptors in the early postnatal period on glutathione and sulfur amino acid levels in the rat brain as a potential causative factor of schizophrenia-like behavior in adulthood.Pharmacological reports : PR · 2024Article
- Treatment Analysis of Very Early and Early Onset Psychosis in the Youth Inpatient Setting.HCA healthcare journal of medicine · 2024Article
- Lost in Translation: Challenges in the Diagnosis and Treatment of Early-Onset Schizophrenia.Cureus · 2023Review
- Association between obsessive-compulsive disorder and the risk of schizophrenia using the Korean National Health Insurance Service-National Sample Cohort: a retrospective cohort study.Epidemiology and psychiatric sciences · 2023Article
- Neurodevelopmental Disorders, Schizophrenia Spectrum Disorders and Catatonia: The "Iron Triangle" Rediscovered in a Case Report.Children (Basel, Switzerland) · 2022Article
- Accelerating the Availability of Medications to Pediatric Patients by Optimizing the Use of Extrapolation of Efficacy.Therapeutic innovation & regulatory science · 2022Review
- Disassociated and concurrent structural and functional abnormalities in the drug-naïve first-episode early onset schizophrenia.Brain imaging and behavior · 2022Article
- Article
- The Effect of Glutathione Deficit During Early Postnatal Brain Development on the Prepulse Inhibition and Monoamine Levels in Brain Structures of Adult Sprague-Dawley Rats.Neurotoxicity research · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Structural brain abnormalities have become an established feature of schizophrenia and increasing evidence points towards the progressive nature of these abnormalities. The brain abnormalities are most profound in early onset cases, which have a severe, treatment refractory phenotype and more salient genetic features. Unique insights could thus be gained in schizophrenia pathology from studying the earliest manifestations of the illness. This paper reviews and updates the findings on anatomic brain development in patients with very early onset schizophrenia while showing preliminary data from ongoing studies. Collectively, our studies demonstrate that childhood-onset schizophrenia (COS) subjects show progressive loss of gray matter, delayed/disrupted white matter (WM) growth, and a progressive decline in cerebellar volume, some of which are shared by their healthy siblings. The developmental patterns or the 'trajectories' of brain development are often more striking than anatomic brain differences at any one point in time; highlighting the importance of longitudinal studies. The sibling findings of partially shared gray matter (GM) deficits which appear to normalize with age, along with other genetic analyses, provide evidence that the brain developmental 'patterns/trajectories' for several regions at particular ages could be useful endophenotypes (trait markers).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.