ArticleNeuroscience research2011
A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: altered l-serine level associated with disruption of PSAT1 gene expression.
Article in Neuroscience research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 41 citations in OpenAlex.
- Pharmacological and toxicological insights into the ayurvedic formulation Rasasindura.Scientific reports · 2025Article
- Hub genes, a diagnostic model, and immune infiltration based on ferroptosis-linked genes in schizophrenia.IBRO neuroscience reports · 2024Article
- PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis.Journal of translational medicine · 2023Article
- L-serine synthesis via the phosphorylated pathway in humans.Cellular and molecular life sciences : CMLS · 2020Review
- Host-parasite interaction associated with major mental illness.Molecular psychiatry · 2020Article
- GlutathioneScience signaling · 2019Article
- Oxytocin pathway gene networks in the human brain.Nature communications · 2019Article
- Analysis of Gene Expression Variance in Schizophrenia Using Structural Equation Modeling.Frontiers in molecular neuroscience · 2018Article
- Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice.Molecular psychiatry · 2016Article
- Protein expression profiles characterize distinct features of mouse cerebral cortices at different developmental stages.PloS one · 2015Article
- Unique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control.Translational psychiatry · 2013Article
- Metabolomic analysis reveals metabolic disturbance in the cortex and hippocampus of subchronic MK-801 treated rats.PloS one · 2013Article
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Authors and funding
15 authors at 9 institutions in 3 countries.
Funding
Abstract
l-Serine is required for the synthesis of glycine and d-serine, both of which are NMDA receptor co-agonists. Although roles for d-serine and glycine have been suggested in schizophrenia, little is known about the role of the l-serine synthesizing cascade in schizophrenia or related psychiatric conditions. Here we report a patient with schizophrenia carrying a balanced chromosomal translocation with the breakpoints localized to 3q13.12 and 9q21.2. We examined this proband and her son with schizotypal personality disorder for chromosomal abnormalities, molecular expression profiles, and serum amino acids. Marked decrease of l-serine and glutamate was observed in the sera of the patient and her son, compared with those in normal controls. Interestingly, expression of PSAT1 gene, which is located next to the breakpoint and encodes one of the enzymes in the l-serine synthesizing cascade, was reduced in both patient and her son. Direct effect of impaired PSAT1 gene expression on decreased serum l-serine level was strongly implicated by rat astrocyte experiments. In summary, we propose an idea that PSAT1 may be implicated in altered serine metabolism and schizophrenia spectrum conditions.
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