ArticleBehavioral and brain functions : BBF2010
Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats.
Article in Behavioral and brain functions : BBF, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Efficacy and safety of puerarin injection in curing acute ischemic stroke: A meta-analysis of randomized controlled trials.Medicine · 2017Pooled it
- Neural progenitor cell transplantation results in structural and functional recovery in a rat model of cerebral palsy.Iranian journal of basic medical sciences · 2025Article
- Narrative review of stem cell therapy for ischemic brain injury.Translational pediatrics · 2021Review
- Collagen-curcumin nanocomposites showing an enhanced neuroprotective effect against short term focal cerebral ischemia.RSC advances · 2020Article
- The structures and biological functions of polysaccharides from traditional Chinese herbs.Progress in molecular biology and translational science · 2019Review
- HMGB1-mediated apoptosis and autophagy in ischemic heart diseases.Vascular biology (Bristol, England) · 2019Review
- Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury.Experimental and therapeutic medicine · 2017Article
- Entomopathogenicity and Biological Attributes of Himalayan Treasured Fungus Ophiocordyceps sinensis (Yarsagumba).Journal of fungi (Basel, Switzerland) · 2017Review
- Metabolomic profile and nucleoside composition of Cordyceps nidus sp. nov. (Cordycipitaceae): A new source of active compounds.PloS one · 2017Article
- Characterization of a new model of thromboembolic stroke in C57 black/6J mice.Translational stroke research · 2014Article
- Recent advances inJournal of functional foods · 2014Review
- Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats.BMC complementary and alternative medicine · 2013Article
- Properties ofJournal of functional foods · 2013Review
- A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in Dong-ChongXiaCao ( Dōng Chóng Xià Cǎo) and Related Bioactive Ingredients.Journal of traditional and complementary medicine · 2013Review
- Prevention of disuse osteoporosis in rats by Cordyceps sinensis extract.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Article
- Anti-inflammation and antioxidant effect of Cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, in middle cerebral artery occlusion-induced focal cerebral ischemia in rats.Metabolic brain disease · 2012Article
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Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIschemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. From the point of view of "self-medication" or "preventive medicine," Cordyceps sinensis was used in the prevention of cerebral ischemia in this paper.
methodsThe right middle cerebral artery occlusion model was used in the study. The effects of Cordyceps sinensis (Caterpillar fungus) extract on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid Peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+K+ATPase activity and glutathione S transferase activity in a rat model were studied respectively.
resultsCordyceps sinensis extract significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. At the same time, supplementation of Cordyceps sinensis extract significantly boosted the defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may have helped the brain recover from ischemic injury.
conclusionsThese experimental results suggest that complement Cordyceps sinensis extract is protective after cerebral ischemia in specific way. The administration of Cordyceps sinensis extract significantly reduced focal cerebral ischemic/reperfusion injury. The defense mechanism against cerebral ischemia was by increasing antioxidants activity related to lesion pathogenesis.
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