ArticleInternational journal of urology : official journal of the Japanese Urological Association2010
Outcome of different post-orchiectomy management for stage I seminoma: Japanese multi-institutional study including 425 patients.
Article in International journal of urology : official journal of the Japanese Urological Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Testicular germ cell tumours' clinical stage I: comparison of surveillance with adjuvant treatment strategies regarding recurrence rates and overall survival-a systematic review.World journal of urology · 2022Pooled it
- Surveillance versus Adjuvant Treatment with Chemotherapy or Radiotherapy for Stage I Seminoma: A Systematic Review and Meta-Analysis According to EAU COVID-19 Recommendations.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Oncological Follow-up Strategies for Testicular Germ Cell Tumours: A Narrative Review.European urology open science · 2022Review
- Canadian Urological Association consensus guideline: Management of testicular germ cell cancer.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022Article
- Integrated Molecular Analysis Reveals 2 Distinct Subtypes of Pure Seminoma of the Testis.Cancer informatics · 2022Article
- Seminoma Retroperitoneal Relapse 23 Years After Surgery.Oncology and therapy · 2021Article
- The Potential of Artificial Intelligence to Detect Lymphovascular Invasion in Testicular Cancer.Cancers · 2021Article
- Testicular seminoma clinical stage 1: treatment outcome on a routine care level.Journal of cancer research and clinical oncology · 2016Article
- Controversies in the management of clinical stage I testicular seminoma.Central European journal of urology · 2016Article
- Handling and reporting of orchidectomy specimens with testicular cancer: areas of consensus and variation among 25 experts and 225 European pathologists.Histopathology · 2015Article
- A refined risk stratification scheme for clinical stage 1 NSGCT based on evaluation of both embryonal predominance and lymphovascular invasion.Annals of oncology : official journal of the European Society for Medical Oncology · 2015Article
- Advances in the treatment of testicular cancer.Translational andrology and urology · 2015Review
- Evaluation of a prognostic model for risk of relapse in stage I seminoma surveillance.Cancer medicine · 2015Article
- Adjuvant radiotherapy outcome of stage I testicular seminoma: a single institution study.Yonsei medical journal · 2015Article
- [Testicular seminomas. The classical and the less classical ones].Der Pathologe · 2014Review
- Anaplastic variant of classical seminoma of the testis: northern Israel oncology center experience and brief review of literature.Rambam Maimonides medical journal · 2014Article
- Contemporary management of stage I and II seminoma.Current urology reports · 2013Review
- Article
- Pure seminoma: a review and update.Radiation oncology (London, England) · 2011Review
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesTo clarify the contemporary clinical outcome of stage I seminoma and to provide information on treatment options to patients.
methodsA retrospective analysis of 425 patients who underwent orchiectomy for stage I seminoma between 1985 and 2006 at 25 hospitals in Japan. Relapse-free survival rates were calculated using the Kaplan-Meier method and clinicopathological factors associated with relapse were examined by univariate and multivariate analyses using the Cox proportional hazards model.
resultsA total of 30 out of 425 patients had relapsed. Relapse-free survival rates at 10 years were 79, 94 and 94% in the surveillance, chemotherapy and radiotherapy groups, respectively. Post-orchiectomy management and rete testis invasion were identified as independent predictive factors associated with relapse. Rete testis invasion remained to be an independent predictive factor, even if the cases with relapses in the contralateral testis were censored. Only one patient, who relapsed after adjuvant radiotherapy, died of the disease. Overall survival at 10 years was 100, 100 and 99% in the surveillance, chemotherapy and radiotherapy groups, respectively. More than half of the patients were lost to follow up within 5 years.
conclusionsThe outcome of Japanese patients with stage I seminoma is similar to previously published Western reports. Surveillance policy is becoming a popular option in Japan, although the relapse rate in patients opting for surveillance policy is higher than those opting for adjuvant chemotherapy or radiotherapy. Rete testis invasion is an independent predictive factor associated with relapse regardless of the post-orchiectomy management. Long-term follow up is mandatory for detection of late relapse.
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