ArticleExperimental dermatology2011
IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice.
Article in Experimental dermatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Microfluidics Technology for the Design and Formulation of Nanomedicines.Nanomaterials (Basel, Switzerland) · 2021Review
- Variable gene expression and parasite load predict treatment outcome in cutaneous leishmaniasis.Science translational medicine · 2019Article
- Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies.Journal of immunology research · 2019Review
- CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production.PLoS pathogens · 2017Article
- Pro- and anti-inflammatory cytokines in cutaneous leishmaniasis: a review.Pathogens and global health · 2016Review
- Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors.Cellular and molecular life sciences : CMLS · 2016Review
- The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice.European journal of immunology · 2016Article
- Innate immunity against Leishmania infections.Cellular microbiology · 2015Review
- PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection.PLoS neglected tropical diseases · 2015Article
- NLR proteins and parasitic disease.Immunologic research · 2014Review
- Article
- Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania.Nature medicine · 2013Article
- Old World cutaneous leishmaniasis: diagnosis and treatment.Journal of dermatological case reports · 2013Article
- IL-17 mediates immunopathology in the absence of IL-10 following Leishmania major infection.PLoS pathogens · 2013Article
- Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis.Seminars in immunopathology · 2012Review
- Disease severity in patients infected with Leishmania mexicana relates to IL-1β.PLoS neglected tropical diseases · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Leishmaniasis is a parasitic disease affecting ∼12 million people. Control of infection (e.g. in C57BL/6 mice) results from IL-12-dependent production of IFNγ by Th1/Tc1 cells. In contrast, BALB/c mice succumb to infection because of preferential Th2-type cytokine induction. Infected dendritic cells (DC) represent important sources of IL-12. Genetically determined differences in DC IL-1α/β production contribute to disease outcome. Whereas the course of disease was not dramatically altered in IL-1RI(-/-) mice, local administration of IL-1α to infected C57BL/6 mice improved disease outcome. To definitively elucidate the involvement of IL-1 in immunity against leishmaniasis, we now utilized IL-1α/β-double-deficient C57BL/6 mice. C57BL/6 mice are believed to be a good surrogate model for human, self limited cutaneous leishmaniasis (CL). Leishmania major-infected IL-1α/β(-/-) mice were resistant to experimental CL comparable to controls. In addition, DC-based vaccination against leishmaniasis in C57BL/6 mice was independent of IL-1. Thus, in Leishmania-resistant C57BL/6 mice, IL-1 signalling is dispensable for protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.