ArticleJournal of cognitive neuroscience2011
Learning increases the survival of newborn neurons provided that learning is difficult to achieve and successful.
Article in Journal of cognitive neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 63 citations in OpenAlex.
- A combined exercise and cognitive training intervention induces fronto-cingulate cortical plasticity in first-episode psychosis patients.Schizophrenia research · 2023Trial
- Simultaneous Aerobic Exercise and Memory Training Program in Older Adults with Subjective Memory Impairments.Journal of Alzheimer's disease : JAD · 2018Trial
- Modifying Factors of Adult Hippocampal Neurogenesis: A Dorsoventral Perspective in Health and Disease.Cells · 2025Review
- Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024.F1000Research · 2025Article
- Mental and physical training with meditation and aerobic exercise improved mental health and well-being in teachers during the COVID-19 pandemic.Frontiers in human neuroscience · 2022Article
- Adult Hippocampal Neurogenesis and Affective Disorders: New Neurons for Psychic Well-Being.Frontiers in neuroscience · 2021Review
- Behavioral and structural adaptations to stress.Frontiers in neuroendocrinology · 2018Review
- Cortical spreading depolarization increases adult neurogenesis, and alters behavior and hippocampus-dependent memory in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- The role of cognitive activity in cognition protection: from Bedside to Bench.Translational neurodegeneration · 2017Review
- Brain structural changes following adaptive cognitive training assessed by Tensor-Based Morphometry (TBM).Neuropsychologia · 2016Article
- MAP training: combining meditation and aerobic exercise reduces depression and rumination while enhancing synchronized brain activity.Translational psychiatry · 2016Article
- NMDA Receptor Function During Senescence: Implication on Cognitive Performance.Frontiers in neuroscience · 2015Review
- Negative neuroplasticity in chronic traumatic brain injury and implications for neurorehabilitation.Neuropsychology review · 2014Review
- Mental and Physical (MAP) Training: a neurogenesis-inspired intervention that enhances health in humans.Neurobiology of learning and memory · 2014Review
- Physical performance and disability in schizophrenia.Schizophrenia research. Cognition · 2014Article
- Hemispheric asymmetry in new neurons in adulthood is associated with vocal learning and auditory memory.PloS one · 2014Article
- Preparing for adulthood: thousands upon thousands of new cells are born in the hippocampus during puberty, and most survive with effortful learning.Frontiers in neuroscience · 2014Article
- Scale and pattern of atrophy in the chronic stages of moderate-severe TBI.Frontiers in human neuroscience · 2014Article
- Neuronal Rac1 is required for learning-evoked neurogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Training your brain: Do mental and physical (MAP) training enhance cognition through the process of neurogenesis in the hippocampus?Neuropharmacology · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Learning increases neurogenesis by increasing the survival of new cells generated in the adult hippocampal formation [Shors, T. J. Saving new brain cells. Scientific American, 300, 46-52, 2009]. However, only some types of learning are effective. Recent studies demonstrate that animals that learn the conditioned response (CR) but require more trials to do so retain more new neurons than animals that quickly acquire the CR or that fail to acquire the CR. In these studies, task parameters were altered to modify the number of trials required to learn a CR. Here, we asked whether pharmacological manipulations that prevent or facilitate learning would decrease or increase, respectively, the number of cells that remain in the hippocampus after training. To answer this question, we first prevented learning with the competitive N-methyl-D-aspartate (NMDA) receptor antagonist (RS)-3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid. As a consequence, training did not increase cell survival. Second, we facilitated learning with the cognitive enhancer D-cycloserine, which increases NMDA receptor activity via its actions at the glycine binding site. Administration of D-cycloserine each day before training increased the number of learned responses and the number of cells that survived. All animals that learned the CR retained more of the new cells, but those that learned very quickly retained fewer than those that required more training trials to learn. Together, these results demonstrate that NMDA receptor activation modifies learning and as a consequence alters the number of surviving cells in the adult hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.