ArticleAIDS research and human retroviruses2010
Comparison of methods to detect HIV dual infection.
Article in AIDS research and human retroviruses, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- HIV-1 superinfection occurs less frequently than initial infection in a cohort of high-risk Kenyan women.PLoS pathogens · 2013Trial
- Analysis of genetic linkage of HIV from couples enrolled in the HIV Prevention Trials Network 052 trial.The Journal of infectious diseases · 2011Trial
- A graph homomorphism approach for unraveling histories of metastatic cancers and viral outbreaks under evolutionary constraints.Nature communications · 2025Article
- Quantifying prevalence and risk factors of HIV multiple infection in Uganda from population-based deep-sequence data.PLoS pathogens · 2025Article
- VirGenA: a reference-based assembler for variable viral genomes.Briefings in bioinformatics · 2019Article
- HIV-TRACE (TRAnsmission Cluster Engine): a Tool for Large Scale Molecular Epidemiology of HIV-1 and Other Rapidly Evolving Pathogens.Molecular biology and evolution · 2018Article
- Article
- No Substantial Evidence for Sexual Transmission of Minority HIV Drug Resistance Mutations in Men Who Have Sex with Men.Journal of virology · 2017Article
- Dual Infection Contributes to Rapid Disease Progression in Men Who Have Sex With Men in China.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- HIV-associated neurocognitive disorder is associated with HIV-1 dual infection.AIDS (London, England) · 2016Article
- Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.PLoS pathogens · 2016Article
- A Multiplex PCR Approach for Detecting Dual Infections and Recombinants Involving Major HIV Variants.Journal of clinical microbiology · 2016Article
- Possible involvement of distinct phylogenetic clusters of HIV-1 variants in the discrepancies between coreceptor tropism predictions based on viral RNA and proviral DNA.Journal of pharmaceutical health care and sciences · 2016Article
- HIV-1 neutralizing antibody response and viral genetic diversity characterized with next generation sequencing.Virology · 2015Article
- Incidence and prevalence of intrasubtype HIV-1 dual infection in at-risk men in the United States.The Journal of infectious diseases · 2014Article
- Dynamics of viral evolution and neutralizing antibody response after HIV-1 superinfection.Journal of virology · 2013Article
- Frequency and implications of HIV superinfection.The Lancet. Infectious diseases · 2013Review
- Base-calling algorithm with vocabulary (BCV) method for analyzing population sequencing chromatograms.PloS one · 2013Article
- Article
- HIV-1 clade B pol evolution following primary infection.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Current methods to detect intraclade HIV dual infection are poorly suited for determining its prevalence in large cohorts. To investigate the potential of ultra-deep sequencing to screen for dual infection, we compared it to bulk sequence-based synonymous mixture index and the current standard of single genome sequencing. The synonymous mixture index identified samples likely to harbor dual infection, while ultra-deep sequencing captured more intra-host viral diversity than single genome sequencing at approximately 40% of the cost and 20% of the laboratory and analysis time. The synonymous mixture index and ultra-deep sequencing are promising methods for rapid and cost-effective systematic identification of HIV dual infection.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.