ArticleWorld journal of gastroenterology2010
Anti-inflammatory effects of Mangifera indica L. extract in a model of colitis.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Deciphering the molecular mechanism of sesamol in inflammatory bowel disease through an integrative computational and biological evaluation of the JAK1 signalling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Advancements in Enteric-coated Microspheres Formulation Development and Mangiferin Drug Delivery for the Treatment of Ulcerative Colitis.Recent advances in drug delivery and formulation · 2026Article
- Acute Supplementation of Soluble Mango Leaf Extract (ZynamitePharmaceuticals (Basel, Switzerland) · 2025Article
- Article
- Traditional Chinese medicine prescriptions (XJZ, JSS) ameliorate spleen inflammatory response and antioxidant capacity by synergistically regulating NF-κB and Nrf2 signaling pathways in piglets.Frontiers in veterinary science · 2022Article
- Mango (Molecules (Basel, Switzerland) · 2021Review
- Metabolomic Profiling of Mango (Molecules (Basel, Switzerland) · 2020Article
- Prescription Opioids induce Gut Dysbiosis and Exacerbate Colitis in a Murine Model of Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2020Article
- Neuroprotective efficiency of Mangifera indica leaves extract on cadmium-induced cortical damage in rats.Metabolic brain disease · 2018Article
- The impact of mangiferin from Belamcanda chinensis on experimental colitis in rats.Inflammopharmacology · 2018Article
- An Evidence-Based Study on Medicinal Plants for Hemorrhoids in Medieval Persia.Journal of evidence-based complementary & alternative medicine · 2017Review
- Multifaceted Health Benefits of Mangifera indica L. (Mango): The Inestimable Value of Orchards Recently Planted in Sicilian Rural Areas.Nutrients · 2017Review
- A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds ofEvidence-based complementary and alternative medicine : eCAM · 2017Review
- Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo.Molecular carcinogenesis · 2017Article
- Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis.Molecular nutrition & food research · 2016Article
- The standard aqueous stem bark extract of Mangifera indica L. inhibits toxic PLA2 - NN-XIb-PLA2 of Indian cobra venom.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2016Article
- S100A12 concentrations and myeloperoxidase activity in the intestinal mucosa of healthy dogs.BMC veterinary research · 2015Article
- Royal Jelly and its dual role in TNBS colitis in mice.TheScientificWorldJournal · 2015Article
- Mangiferin Mitigates Gastric Ulcer in Ischemia/ Reperfused Rats: Involvement of PPAR-γ, NF-κB and Nrf2/HO-1 Signaling Pathways.PloS one · 2015Article
- The effect of melatonin on plasma markers of inflammation and on expression of nuclear factor-kappa beta in acetic acid-induced colitis in the rat.Digestive diseases and sciences · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of aqueous extract from Mangifera indica L. (MIE) on dextran sulfate sodium (DSS)-induced colitis in rats.
methodsMIE (150 mg/kg) was administered in two different protocols: (1) rectally, over 7 d at the same time as DSS administration; and (2) once daily over 14 d (by oral gavage, 7 d before starting DSS, and rectally for 7 d during DSS administration). General observations of clinical signs were performed. Anti-inflammatory activity of MIE was assessed by myeloperoxidase (MPO) activity. Colonic lipid peroxidation was determined by measuring the levels of thiobarbituric acid reactive substances (TBARS). Reduced glutathione (GSH) levels, expression of inflammatory related mediators [inducible isoforms of nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2, respectively] and cytokines [tumor necrosis factor (TNF)-α and TNF receptors 1 and 2] in colonic tissue were also assessed. Interleukin (IL)-6 and TNF-α serum levels were also measured.
resultsThe results demonstrated that MIE has anti-inflammatory properties by improvement of clinical signs, reduction of ulceration and reduced MPO activity when administered before DSS. In addition, administration of MIE for 14 d resulted in an increase in GSH and reduction of TBARS levels and iNOS, COX-2, TNF-α and TNF R-2 expression in colonic tissue, and a decrease in IL-6 and TNF-α serum levels.
conclusionMIE has anti-inflammatory activity in a DSS-induced rat colitis model and preventive administration (prior to DSS) seems to be a more effective protocol.
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