ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011
Systems genetics analysis of mouse chondrocyte differentiation.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- GPRASP proteins are critical negative regulators of hematopoietic stem cell transplantation.Blood · 2020Article
- Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation.Nature communications · 2019Article
- Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss.Scientific reports · 2016Article
- Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Article
- The systems genetics resource: a web application to mine global data for complex disease traits.Frontiers in genetics · 2013Article
- Systems genetics: a novel approach to dissect the genetic basis of osteoporosis.Current osteoporosis reports · 2012Review
- Genome-wide association of an integrated osteoporosis-related phenotype: is there evidence for pleiotropic genes?Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Article
- Systems genetic analysis of osteoblast-lineage cells.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
One of the goals of systems genetics is the reconstruction of gene networks that underlie key processes in development and disease. To identify cartilage gene networks that play an important role in bone development, we used a systems genetics approach that integrated microarray gene expression profiles from cartilage and bone phenotypic data from two sets of recombinant inbred strains. Microarray profiles generated from isolated chondrocytes were used to generate weighted gene coexpression networks. This analysis resulted in the identification of subnetworks (modules) of coexpressed genes that then were examined for relationships with bone geometry and density. One module exhibited significant correlation with femur length (r = 0.416), anteroposterior diameter (r = 0.418), mediolateral diameter (r = 0.576), and bone mineral density (r = 0.475). Highly connected genes (n = 28) from this and other modules were tested in vitro using prechondrocyte ATDC5 cells and RNA interference. Five of the 28 genes were found to play a role in chondrocyte differentiation. Two of these, Hspd1 and Cdkn1a, were known previously to function in chondrocyte development, whereas the other three, Bhlhb9, Cugbp1, and Spcs3, are novel genes. Our integrative analysis provided a systems-level view of cartilage development and identified genes that may be involved in bone development.
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