ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2011
Exogenous procalcitonin evokes a pro-inflammatory cytokine response.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Aminoprocalcitonin protects against hippocampal neuronal death via preserving oxidative phosphorylation in refractory status epilepticus.Cell death discovery · 2023Article
- Anti-SARS-CoV-2 IgG responses are powerful predicting signatures for the outcome of COVID-19 patients.Journal of advanced research · 2022Article
- Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment.Bone research · 2022Article
- Sputum procalcitonin: a potential biomarker in stable bronchiectasis.ERJ open research · 2021Article
- Kinetics of Neutralizing Antibody Response Underscores Clinical COVID-19 Progression.Journal of immunology research · 2021Article
- Clinical Characteristics, Associated Factors, and Predicting COVID-19 Mortality Risk: A Retrospective Study in Wuhan, China.American journal of preventive medicine · 2020Article
- Overview of procalcitonin in pregnancy and in pre-eclampsia.Clinical and experimental immunology · 2019Review
- Biomarker Guided Diagnosis of Septic Peritonitis in Dogs.Frontiers in veterinary science · 2019Article
- Association between the effect of controlled fluid resuscitation on massive hemorrhage and expression of human neutrophil lipocalin.Experimental and therapeutic medicine · 2018Article
- Plasma procalcitonin concentrations are increased in dogs with sepsis.Veterinary record open · 2018Article
- Procalcitonin: Is This the Promised Biomarker for Critically Ill Patients?Journal of pediatric intensive care · 2016Review
- Procalcitonin: present and future.Irish journal of medical science · 2015Review
- Article
- Effects of cyclic equibiaxial mechanical stretch on α-BK and TRPV4 expression in equine chondrocytes.SpringerPlus · 2014Article
- Clinical significance of serum procalcitonin in patients with ulcerative colitis.World journal of gastroenterology · 2013Article
- Substantially elevated C-reactive protein (CRP), together with low levels of procalcitonin (PCT), contributes to diagnosis of fungal infection in immunocompromised patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Article
- Procalcitonin beyond the acute phase: novel biomediator properties?BMC medicine · 2013Article
- Plasma procalcitonin is associated with all-cause and cancer mortality in apparently healthy men: a prospective population-based study.BMC medicine · 2013Article
- Intravenous immunoglobulin prevents release of proinflammatory cytokines in human monocytic cells stimulated with procalcitonin.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Procalcitonin neutralizes bacterial LPS and reduces LPS-induced cytokine release in human peripheral blood mononuclear cells.BMC microbiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designProcalcitonin (ProCT) is increased in serum of septic patients and those with systemic inflammation. Endogenous levels of ProCT might influence the response of polymorphonuclear leukocytes (PMNs), independently of endotoxin, in clinical disease. SUBJECTS: Healthy human volunteers. TREATMENT: Recombinant human ProCT (rhProCT).
methodsWhole blood and PMNs were exposed in vitro to exogenous rhProCT. Interleukin (IL)-6, IL-8, IL-10, IL-13, tumor necrosis factor-alpha (TNFα), IL-1β, and macrophage inflammatory protein (MIP)-1β (pg/ml) were measured by multiplex suspension bead-array immunoassay, and migration and phagocytosis were measured in PMNs.
resultsIn a whole-blood model, a dose-dependent increase in IL-6, TNFα, and IL-1β of the cell-free supernatant was noted. Pre-incubation with ProCT, at doses consistent with clinical sepsis, resulted in a decrease in PMN migration without alteration in phagocytosis of Staphylococcus aureus or indirect measurements of bacterial killing.
conclusionClinically relevant levels of ProCT influence immunologic responses that may contribute to systemic inflammatory response and septic shock.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.