ReviewQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2010
I'm so tired: biological and genetic mechanisms of cancer-related fatigue.
Review in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05067777 (Massage for Prostate Cancer-Related Fatigue), which is not on this map. Cited by 102 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Massage for Prostate Cancer-Related Fatigue (mPROSTATE)
Who cites it
102 citing papers in PubMed, 3 syntheses or guidelines pooled it, 194 citations in OpenAlex.
- Effect of exercise interventions in adults with cancer receiving palliative care: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- Interventions for multidimensional aspects of breast cancer-related fatigue: a meta-analytic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Pooled it
- Severe fatigue after treatment for childhood cancer.The Cochrane database of systematic reviews · 2020Pooled it
- Melatonin Supplementation for Cancer-Related Fatigue in Patients With Early Stage Breast Cancer Receiving Radiotherapy: A Double-Blind Placebo-Controlled Trial.The oncologist · 2024Trial
- Impact of Adjunct Testosterone on Cancer-Related Fatigue: An Ancillary Analysis from a Controlled Randomized Trial.Current oncology (Toronto, Ont.) · 2022Trial
- Efficacy and safety of bupropion in cancer-related fatigue, a randomized double blind placebo controlled clinical trial.BMC cancer · 2020Trial
- Impacts of GRIN3A, GRM6 and TPH2 genetic polymorphisms on quality of life in methadone maintenance therapy population.PloS one · 2018Trial
- Cognitive behavioral therapy for insomnia, but not armodafinil, improves fatigue in cancer survivors with insomnia: a randomized placebo-controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Trial
- Quality of life, immunomodulation and safety of adjuvant mistletoe treatment in patients with gastric carcinoma - a randomized, controlled pilot study.BMC complementary and alternative medicine · 2012Trial
- Thyrotropin-releasing hormone as a treatment for cancer-related fatigue: a randomized controlled study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012Trial
- Acupuncture improves health-related quality-of-life (HRQoL) and sleep in women with breast cancer and hot flushes.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012Trial
- Recent advances in understanding chemotherapy-induced fatigue in BC patients residing in high-altitude regions: a review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
- Article
- Sex-, Age-, Lifestyle-, and Comorbidity-Specific Reference Values for Serum Cytokines in the Dutch General Population: Results From the PROFILES Registry.Cancer medicine · 2026Article
- An exploratory analysis of 24-h movement behaviors in individuals with cancer completing a 12-week resistance exercise intervention.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Understanding, Recognizing, and Managing Cancer-Related Fatigue Associated with Breast Cancer.Current treatment options in oncology · 2026Review
- Remote blood collection among cancer patients and age- and sex-matched controls for biomarker and genetic analyses using the PROFILES registry.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
- Herbal and pharmacological treatments in cancer-related fatigue.Translational gastroenterology and hepatology · 2026Article
- Genetic predisposition to persistent fatigue after a diagnosis of colorectal cancer.Journal of the National Cancer Institute · 2025Article
- Prunella vulgaris seed oil alleviates cancer related fatigue through hypothalamic inflammation and CRH regulation.NPJ science of food · 2025Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveThe goal of this paper is to discuss cancer-related fatigue (CRF) and address issues related to the investigation into potential biological and genetic causal mechanisms. The objectives are to: (1) describe CRF as a component of quality of life (QOL); (2) address measurement issues that have slowed progress toward an understanding of mechanisms underlying this symptom; (3) review biological pathways and genetic approaches that have promise for the exploration of causal mechanisms of CRF; and (4) offer directions for future research.
methodsReview, synthesis, and interpretation of the literature.
resultsUntil recently, CRF and QOL have been understood primarily as subjective patient-reported experiences. With increased understanding of human genetics, theories and research are being expanded to incorporate biological and genetic understandings of these subjective experiences. Proposed biological and genetic mechanisms of CRF that have been examined include cytokine dysregulation, hypothalamic-pituitary-adrenal (HPA) axis dysfunction, five hydroxy tryptophan (5-HT) neurotransmitter dysregulation, circadian rhythm disruption, alterations in adenosine triphosphate (ATP) and muscle metabolism, and vagal afferent activation. Approaches to the study of genetic mechanisms have also been addressed including candidate genes, genome-wide scanning, and gene expression. Based on the review and synthesis of the literature, directions for future research are proposed.
conclusionsUnderstanding the biological and genetic basis of CRF has the potential to contribute to a more complete understanding of the genetic determinants of QOL.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.