Evidence map›Paper›PMID 20953825›Full record

ArticleJournal of fluorescence2011

A series of carbazole cationic compounds with large two-photon absorption cross sections for imaging mitochondria in living cells with two-photon fluorescence microscopy.

Xin Liu, Yuming Sun, Yuanhong Zhang, Ning Zhao, Hongshi Zhao, Guancong Wang, Xiaoqiang Yu, Hong Liu

Abstract read
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In one paragraph

Article in Journal of fluorescence, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xin LiuState Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, People's Republic of China.
Yuming Sun
Yuanhong Zhang
Ning Zhao
Hongshi Zhao
Guancong Wang
Xiaoqiang Yu
Hong Liu
Shandong University · CNState Key Laboratory of Crystal Materials

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of carbazole cationic compounds based on donor- Π-acceptor (D-Π-A) structure were synthesized and characterized. They exhibit large two-photon absorption cross sections when excited by a 810 nm a laser beam, and their photophysical properties show that the intramolecular charge transfer (ICT) character is predominant. Moreover these compounds can easily pass though the intact cell membrane of living cells, amongst, 3-(1-hydroxyethyl-4-vinylpyridium iodine)-N-butyl carbazole (9B-HVC) has been proven to be capable of accumulating within the mitochondria possessing large membrane potential and imaging this organelle in living cells by means of two-photon fluorescence microscopy. At the same time usable fluorescent photos can be obtained at lower incident excitation power (5 mW) and low-micromolar concentrations (2 μM), which does not result in significant reduction in cell viability over a period of at least 24 h.

Indexed as

PhotonsAbsorptionCarbazolesCell Line, TumorCell SurvivalHumansMicroscopy, FluorescenceMitochondriaMolecular ImagingCarbazoles

Identifiers

PMID20953825
OpenAlexW2027489475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.