ArticleMolecular and cellular biochemistry2011
Interleukin-10 -1082 promoter polymorphism and gastric cancer risk in a Chinese Han population.
Article in Molecular and cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- The -1082A>G polymorphism in promoter region of interleukin-10 and risk of digestive cancer: a meta-analysis.Scientific reports · 2014Pooled it
- Association of IL-10-1082 promoter polymorphism with susceptibility to gastric cancer: evidence from 22 case-control studies.Molecular biology reports · 2012Pooled it
- A meta-analysis of interleukin-10-1082 promoter polymorphism associated with gastric cancer risk.DNA and cell biology · 2012Pooled it
- Identification of crucial genes involved in thyroid cancer development.Journal of the Egyptian National Cancer Institute · 2023Review
- Association ofCanadian journal of gastroenterology & hepatology · 2021Review
- Long-term comparisons of the efficacy, safety, and pregnancy outcomes of adjuvant tamoxifen plus ovarian function suppression in premenopausal Han and Zhuang Chinese patients with hormone receptor-positive early breast cancer.The Journal of international medical research · 2019Article
- Association of three promoter polymorphisms in interleukin-10 gene with cancer susceptibility in the Chinese population: a meta-analysis.Oncotarget · 2017Article
- Association of interleukin-10 promoter polymorphisms and corresponding plasma levels with susceptibility to laryngeal squamous cell carcinoma.Oncology letters · 2014Article
- Interleukin-10-1082 gene polymorphism is associated with papillary thyroid cancer.Molecular biology reports · 2014Article
- Genotyping of IL-8-251 T > A yields prognostic information in patients with gastric carcinoma.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2013Article
- Genetic association between selected cytokine genes and glioblastoma in the Han Chinese population.BMC cancer · 2013Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies investigating the association between interleukin-10 (IL-10) -1082 promoter polymorphism and gastric cancer risk report conflicting results. Our recent meta-analysis suggests that the IL-10 -1082 promoter polymorphism may be associated with gastric cancer among Asians. The objective of this study was to investigate the association between IL-10 -1082 promoter polymorphism and gastric cancer risk in Chinese Han patients. We extracted the peripheral blood samples in 150 patients with gastric cancer and 150 controls. PCR-RFLP analysis was performed to detect IL-10 -1082 promoter polymorphism in these patients. Patients with gastric cancer had a significantly lower frequency of AA (OR = 0.45, 95% CI = 0.27, 0.76; P = 0.003) than controls. Patients with cardia gastric cancer had a significantly higher frequency of GG (OR = 2.17, 95% CI = 1.08, 4.38; P = 0.03) than those with noncardia gastric cancer. Patients with advanced gastric cancer had a significantly higher frequency of AA (OR = 5.21, 95% CI = 1.71, 15.87; P = 0.004) than those with early gastric cancer. When stratified by the Lauren's classification, histological differentiation of gastric cancer, no statistically significant results were observed. This study suggests that the IL-10 -1082 promoter polymorphism may be associated with gastric cancer in Chinese Han patients, and that difference in genotype distribution may be associated with the location and stage of gastric cancer.
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