ArticleEuropean journal of pediatrics2011
Association between toll-like receptor 10 (TLR10) gene polymorphisms and childhood IgA nephropathy.
Article in European journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Association Between HLA Alleles and IgA Nephropathy in a Taiwanese Population.International journal of molecular sciences · 2026Article
- Updates on Toll-Like Receptor 10 Research.European journal of immunology · 2025Review
- TLR10 (CD290) Is a Regulator of Immune Responses in Human Plasmacytoid Dendritic Cells.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics.Immune network · 2020Review
- IRAK2 and TLR10 confer risk of Hashimoto's disease: a genetic association study based on the Han Chinese population.Journal of human genetics · 2019Article
- New insights into the pathogenesis of IgA nephropathy.Pediatric nephrology (Berlin, Germany) · 2018Review
- International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease.Pharmacological reviews · 2015Review
- Toll-like receptor 10-1-6 gene cluster polymorphisms are not associated with benign prostatic hyperplasia in korean population.International neurourology journal · 2014Article
- Allogeneic bone marrow transplantation appears to ameliorate IgA nephropathy in a patient with X-linked thrombocytopenia.Journal of clinical immunology · 2014Article
- A polymorphism of interleukin-22 receptor alpha-1 is associated with the development of childhood IgA nephropathy.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2013Article
- Clinicopathological and immunohistological features in childhood IgA nephropathy: a single-centre experience.Clinical kidney journal · 2013Article
- Toll-like receptors of deuterostome invertebrates.Frontiers in immunology · 2012Article
- IgA Nephropathy: Emerging Mechanisms of Disease.Indian journal of nephrologyReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptors (TLRs) play an important role in the induction and regulation of the innate immune system and adaptive immune responses. TLR10 gene polymorphisms have been reported to be associated with a range of immune-related diseases. In this study, we investigated the association of TLR10 gene polymorphisms with immunoglobulin A nephropathy (IgAN) in Korean children. To examine the association, we genotyped one promoter single nucleotide polymorphisms (SNP) [rs10004195 (-113T/A)] and three missense SNPs [rs11096957 (Asn241His), rs11096955 (Ile369Leu), and rs4129009 (Ile775Val)] using direct sequencing in 199 IgAN patients and 289 control subjects. Our case-control analysis showed that rs10004195 was associated with IgAN (codominant model, p = 0.016 in TT vs. TA; p = 0.044 in TT vs. AA; dominant model, p = 0.0068). In addition, when comparing the proteinuria level of IgAN patients according to the genotypes of each SNP, we found that in dominant model of rs1004195, the level of proteinuria of patients with TA or AA genotypes (median, 4.01 mg/m(2)/h) was higher than that of patients with TT genotype (2.00 mg/m²/h, p = 0.033). In conclusion, these results suggest that TLR10 gene may be associated with susceptibility to IgAN in Korean children.
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