ArticleNeurotoxicity research2011
Influence of physical exercise on neuroimmunological functioning and health: aging and stress.
Article in Neurotoxicity research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 80 citations in OpenAlex.
- Well-Being, Inflammation, and Physical Activity in Acute and Chronic Back Pain: A Cross-Sectional Analysis of 22,864 UK Biobank Participants.European journal of pain (London, England) · 2025Article
- Article
- Exercise and PTSD.Current topics in behavioral neurosciences · 2024Review
- A Comprehensive Review on Neuroimmunology: Insights from Multiple Sclerosis to Future Therapeutic Developments.Biomedicines · 2023Review
- Occupational physical activity: the good, the bad, and the proinflammatory.Frontiers in medicine · 2023Review
- Neutralizing a Springboard for Inflammation: Physical Activity to Control the Immune Network.Healthcare (Basel, Switzerland) · 2021Article
- Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation.Frontiers in psychiatry · 2019Review
- Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging.Neural plasticity · 2017Review
- Physical Exercise Interventions for Drug Addictive Disorders.Journal of reward deficiency syndrome and addiction science · 2017Article
- Engaging cognitive circuits to promote motor recovery in degenerative disorders. exercise as a learning modality.Journal of human kinetics · 2016Article
- Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder.Neurotoxicity research · 2015Review
- "Boomerang Neuropathology" of Late-Onset Alzheimer's Disease is Shrouded in Harmful "BDDS": Breathing, Diet, Drinking, and Sleep During Aging.Neurotoxicity research · 2015Review
- Biological mechanisms underlying the role of physical fitness in health and resilience.Interface focus · 2014Review
- Article
- Altered cytokine and BDNF levels in autism spectrum disorder.Neurotoxicity research · 2013Article
- Epigenetic Modulation of Mood Disorders.Journal of genetic syndromes & gene therapy · 2013Article
- The Use of Multiple Correspondence Analysis to Explore Associations between Categories of Qualitative Variables in Healthy Ageing.Journal of aging research · 2013Article
- Neurogenesis, exercise, and cognitive late effects of pediatric radiotherapy.Neural plasticity · 2013Review
- Influence of physical exercise on traumatic brain injury deficits: scaffolding effect.Neurotoxicity research · 2012Review
- Delayed exercise-induced functional and neurochemical partial restoration following MPTP.Neurotoxicity research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic and acute stress, with associated pathophysiology, are implicated in a variety of disease states, with neuroimmunological dysregulation and inflammation as major hazards to health and functional sufficiency. Psychosocial stress and negative affect are linked to elevations in several inflammatory biomarkers. Immunosenescence, the deterioration of immune competence observed in the aged aspect of the life span, linked to a dramatic rise in morbidity and susceptibility to diseases with fatal outcomes, alters neuroimmunological function and is particularly marked in the neurodegenerative disorders, e.g., Parkinson's disease and diabetes. Physical exercise diminishes inflammation and elevates agents and factors involved in immunomodulatory function. Both the alleviatory effects of life-long physical activity upon multiple cancer forms and the palliative effects of physical activity for individuals afflicted by cancer offer advantages in health intervention. Chronic conditions of stress and affective dysregulation are associated with neuroimmunological insufficiency and inflammation, contributing to health risk and mortality. Physical exercise regimes have induced manifest anti-inflammatory benefits, mediated possibly by brain-derived neurotrophic factor. The epidemic proportions of metabolic disorders, obesity, and diabetes demand attention; several variants of exercise regimes have been found repeatedly to induce both prevention and improvement under both laboratory and clinical conditions. Physical exercise offers a unique non-pharmacologic intervention incorporating multiple activity regimes, e.g., endurance versus resistance exercise that may be adapted to conform to the particular demands of diagnosis, intervention and prognosis inherent to the staging of autoimmune disorders and related conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.