ArticleEvidence-based complementary and alternative medicine : eCAM2011
Evaluation of traditional Indian antidiabetic medicinal plants for human pancreatic amylase inhibitory effect in vitro.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 160 citations in OpenAlex.
- LC-MS/MS-based metabolomic profiling of Syzygium cumini (L.) Skeels identifies key phytochemicals associated with α-amylase inhibition and antioxidant activity.Scientific reports · 2026Article
- Phytochemical Analysis, GC-MS Chemical Profiling, and In Vitro Antidiabetic Evaluation of South AfricanCurrent issues in molecular biology · 2026Article
- Phytochemical profiles, chemical composition, molecular docking, and antibacterial activity of theOpen veterinary journal · 2025Article
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- Use of Complementary and Alternative Medicine Among Patients With Diabetes Mellitus: A Cross-Sectional Study.Cureus · 2024Article
- Ethnobotanical assessment of antidiabetic medicinal plants in District Karak, Pakistan.BMC complementary medicine and therapies · 2024Article
- Investigation of alpha amylase inhibitors fromIn silico pharmacology · 2024Article
- Natural Inhibitors of Mammalian α-Amylases as Promising Drugs for the Treatment of Metabolic Diseases.International journal of molecular sciences · 2023Review
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- Phytochemical Profile, Biological Properties, and Food Applications of the Medicinal PlantFoods (Basel, Switzerland) · 2022Review
- IntegratingEvidence-based complementary and alternative medicine : eCAM · 2022Article
- A Comprehensive Review on the Therapeutic Potential ofFrontiers in pharmacology · 2022Review
- Anti-Diabetic Potential of Plant-Based Pentacyclic Triterpene Derivatives: Progress Made to Improve Efficacy and Bioavailability.Molecules (Basel, Switzerland) · 2021Review
- Prevalence and correlates of complementary and alternative medicine use among diabetic patients in a resource-limited setting.Metabolism open · 2021Article
- Antioxidant-RichPlants (Basel, Switzerland) · 2021Article
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- Gene ontology enrichment analysis of α-amylase inhibitors fromJournal of diabetes and metabolic disorders · 2020Article
- Complementary and alternative medicine use among patients with type 2 diabetes living in the United Arab Emirates.BMC complementary medicine and therapies · 2020Article
- A Comprehensive Review of the Phytochemical, Pharmacological, and Toxicological Properties ofBiomolecules · 2020Review
- Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening.Molecules (Basel, Switzerland) · 2019Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post prandial hyperglycemia via control of starch breakdown. Eleven Ayurvedic Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory potential on pancreatic α-amylase. Analysis of 91 extracts, showed that 10 exhibited strong Human Pancreatic Amylase (HPA) inhibitory potential. Of these, 6 extracts showed concentration dependent inhibition with IC(50) values, namely, cold and hot water extracts from Ficus bengalensis bark (4.4 and 125 μgmL(-1)), Syzygium cumini seeds (42.1 and 4.1 μgmL(-1)), isopropanol extracts of Cinnamomum verum leaves (1.0 μgmL(-1)) and Curcuma longa rhizome (0.16 μgmL(-1)). The other 4 extracts exhibited concentration independent inhibition, namely, methanol extract of Bixa orellana leaves (49 μgmL(-1)), isopropanol extract from Murraya koenigii leaves (127 μgmL(-1)), acetone extracts from C. longa rhizome (7.4 μgmL(-1)) and Tribulus terrestris seeds (511 μgmL(-1)). Thus, the probable mechanism of action of the above fractions is due to their inhibitory action on HPA, thereby reducing the rate of starch hydrolysis leading to lowered glucose levels. Phytochemical analysis revealed the presence of alkaloids, proteins, tannins, cardiac glycosides, flavonoids, saponins and steroids as probable inhibitory compounds.
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Registered trials
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