ArticleEvidence-based complementary and alternative medicine : eCAM2011
Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Toxicological Evaluation of the Liver and Kidneys of Rats Exposed toJournal of experimental pharmacology · 2026Article
- Phytochemistry and Biological Activities of Agrostemma Genus-A Review.Plants (Basel, Switzerland) · 2024Review
- Article
- Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence.Plants (Basel, Switzerland) · 2021Article
- Assessment of Larval Toxicity and the Teratogenic Effect of Three Medicinal Plants Used in the Traditional Treatment of Urinary Tract Infections in Benin.BioMed research international · 2021Article
- Hypolipidemic and Antioxidant Activities ofCardiovascular & hematological agents in medicinal chemistry · 2019Article
- Medicinal plants of the family Caryophyllaceae: a review of ethno-medicinal uses and pharmacological properties.Integrative medicine research · 2015Review
- Effects of Gelam and Acacia honey acute administration on some biochemical parameters of Sprague Dawley rats.BMC complementary and alternative medicine · 2014Article
- The extended statistical analysis of toxicity tests using standardised effect sizes (SESs): a comparison of nine published papers.PloS one · 2014Article
- Safety assessment of zigbir®: a polyherbal formulation in sprague-dawley rats.Journal of toxicology · 2012Article
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8 authors.
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Abstract
Corrigiola telephiifolia Pourr. (Caryophyllaceae) is a Moroccan medicinal plant. Despite its popular usage, no study has been published concerning its toxicological profile. The acute toxicity of C. telephiifolia root extract was evaluated by giving it orally to mice at single doses of 5000, 10000, and 14000 mg/kg bodyweight. The extract was also administered at doses of 5, 70, and 2000 mg/kg bodyweight per day to rats for a forty-day toxicity study. No mortality or signs of toxicity were observed in the acute study. In the forty-day study in rats, the extract at 5 mg/kg/day showed no toxicological effects in either sex. At 70 mg/kg/day, the treated group differed from the control only by a significant decrease in serum concentrations of sodium and chloride ions (P < .05). At the dose of 2000 mg/kg/day, the extract significantly increased the serum concentrations of creatinine, alkaline phosphatase, gamma-glutamyltransferase and phosphorus (P < .05) all suggestive of functional nephrotoxicity and hepatotoxicity. The relative bodyweight of both sexes decreased at the dose of 2000 mg/kg/day, with a fast recovery for males. Histological examination did not reveal any treatment-related effects. In conclusion, Corrigiola extract appears safe at the doses used ethno-medicinally. Much higher doses pose toxicological risks.
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