ArticleEvidence-based complementary and alternative medicine : eCAM2011
Electroacupuncture inhibits inflammation reaction by upregulating vasoactive intestinal Peptide in rats with adjuvant-induced arthritis.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The effect of acupuncture on pain and swelling of arthritis animal models: A systematic review and meta-analysis.Frontiers in genetics · 2023Pooled it
- The effects of acupuncture and related techniques on patients with rheumatoid arthritis: A systematic review and meta-analysis.Journal of the Chinese Medical Association : JCMA · 2022Pooled it
- Acupuncture at KI3 in healthy volunteers induces specific cortical functional activity: an fMRI study.BMC complementary and alternative medicine · 2015Trial
- Efficacy of electro-acupuncture at "Weizhong" (BL40) on macrophage polarization in rats with injured lumbar multifidus.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
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- Modulation of Brain Network Topological Properties in Knee Osteoarthritis by Electroacupuncture in Rats.Journal of pain research · 2023Article
- Efficacy of Moxa-burning heat stimulating Zusanli (ST36) and Shenshu (BL23) on expressions of macrophage migration inhibitory factor and macrophage apoptosis in rabbits with adjuvant-induced arthritis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Article
- Effects of administration of αMolecular pain · 2022Article
- Evaluation of electroacupuncture for symptom modification in a rodent model of spontaneous osteoarthritis.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2021Article
- Laser acupuncture for refractory coccydynia after traumatic coccyx fracture: A case report.Medicine · 2020Article
- Electroacupuncture Alleviates Osteoarthritis by Suppressing NLRP3 Inflammasome Activation in Guinea Pigs.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Effect of electroacupuncture at the ST36 and GB39 acupoints on apoptosis by regulating the p53 signaling pathway in adjuvant arthritis rats.Molecular medicine reports · 2019Article
- Electroacupuncture Pretreatment Attenuates Inflammatory Lung Injury After Cardiopulmonary Bypass by Suppressing NLRP3 Inflammasome Activation in Rats.Inflammation · 2019Article
- Electroacupuncture on ST36 and GB39 Acupoints Inhibits Synovial Angiogenesis via Downregulating HIF-1Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Manual acupuncture relieves bile acid-induced itch in mice: the role of microglia and TNF-α.International journal of medical sciences · 2018Article
- Clinical Efficacy of Acupuncture on Rheumatoid Arthritis and Associated Mechanisms: A Systemic Review.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Article
- Electroacupuncture alleviates retrieval of pain memory and its effect on phosphorylation of cAMP response element-binding protein in anterior cingulate cortex in rats.Behavioral and brain functions : BBF · 2015Article
- The effect of electroacupuncture on osteosarcoma tumor growth and metastasis: analysis of different treatment regimens.Evidence-based complementary and alternative medicine : eCAM · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acupuncture is emerging as an alternative therapy for rheumatoid arthritis (RA). However, the molecular mechanism underlying this beneficial effect of acupuncture has not been fully understood. Here, we demonstrated that electroacupuncture at acupoints Zusanli (ST36), Xuanzhong (GB39); and Shenshu (BL23) markedly decreased the paw swelling and the histologic scores of inflammation in the synovial tissue, and reduced the body weight loss in an adjuvant-induced arthritis rat model. However, the electrical stimulation at nonacupoint did not produce any beneficial effects against the experimental arthritis. Most interestingly, the electroacupuncture treatment resulted in an enhanced immunostaining for vasoactive intestinal peptide (VIP), a potent anti-inflammatory neuropeptide, in the synovial tissue. Moreover, the VIP-immunostaining intensity was significantly negatively correlated with the scores of inflammation in the synovial tissue (r = -0.483, P = .0026). In conclusion, these findings suggest that electroacupuncture may offer therapeutic benefits for the treatment of RA, at least partially through the induction of VIP expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.