ArticleCurrent gerontology and geriatrics research2010
Dynamic determinants of longevity and exceptional health.
Article in Current gerontology and geriatrics research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- The Strehler-Mildvan correlation as a valuable tool for monitoring the long-term health status of a population.Frontiers in public health · 2025Article
- HALL: a comprehensive database for human aging and longevity studies.Nucleic acids research · 2024Article
- How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis.Frontiers in aging · 2024Article
- The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations.Experimental gerontology · 2018Review
- Dynamics of biomarkers in relation to aging and mortality.Mechanisms of ageing and development · 2016Review
- Complex systems dynamics in aging: new evidence, continuing questions.Biogerontology · 2016Review
- Optimal Versus Realized Trajectories of Physiological Dysregulation in Aging and Their Relation to Sex-Specific Mortality Risk.Frontiers in public health · 2016Article
- Article
- Select aging biomarkers based on telomere length and chronological age to build a biological age equation.Age (Dordrecht, Netherlands) · 2014Article
- Joint Analyses of Longitudinal and Time-to-Event Data in Research on Aging: Implications for Predicting Health and Survival.Frontiers in public health · 2014Review
- How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data.Frontiers in genetics · 2013Article
- How genes influence life span: the biodemography of human survival.Rejuvenation research · 2012Article
- Increase in circulating levels of IGF-1 and IGF-1/IGFBP-3 molar ratio over a decade is associated with colorectal adenomatous polyps.International journal of cancer · 2012Article
- Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging.Scientifica · 2012Article
- Age trajectories of physiological indices in relation to healthy life course.Mechanisms of ageing and development · 2011Article
- Biodemographic Analyses of Longitudinal Data on Aging, Health, and Longevity: Recent Advances and Future Perspectives.Advances in geriatricsArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
It is well known from epidemiology that values of indices describing physiological state in a given age may influence human morbidity and mortality risks. Studies of connection between aging and life span suggest a possibility that dynamic properties of age trajectories of the physiological indices could also be important contributors to morbidity and mortality risks. In this paper we use data on longitudinal changes in body mass index, diastolic blood pressure, pulse pressure, pulse rate, blood glucose, hematocrit, and serum cholesterol in the Framingham Heart Study participants, to investigate this possibility in depth. We found that some of the variables describing individual dynamics of the age-associated changes in physiological indices influence human longevity and exceptional health more substantially than the variables describing physiological state. These newly identified variables are promising targets for prevention aiming to postpone onsets of common elderly diseases and increase longevity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.