ArticleEvidence-based complementary and alternative medicine : eCAM2011
Growth Inhibition and Induction of Apoptosis in SHG-44 Glioma Cells by Chinese Medicine Formula "Pingliu Keli".
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Partial response to Chinese patent medicine Kangliu pill for adult glioblastoma: A case report and review of the literature.World journal of clinical cases · 2021Article
- Role of miR-223-3p in pulmonary arterial hypertension via targeting ITGB3 in the ECM pathway.Cell proliferation · 2019Article
- Effects of titanium dioxide nanoparticles derived from consumer products on the marine diatom Thalassiosira pseudonana.Environmental science and pollution research international · 2016Article
- Release and toxicity comparison between industrial- and sunscreen-derived nano-ZnO particles.International journal of environmental science and technology : IJEST · 2016Article
- Article
- Effect of Guibi-Tang, a Traditional Herbal Formula, on Retinal Neovascularization in a Mouse Model of Proliferative Retinopathy.International journal of molecular sciences · 2015Article
- Docosahexaenoic Acid Induces Cell Death in Human Non-Small Cell Lung Cancer Cells by Repressing mTOR via AMPK Activation and PI3K/Akt Inhibition.BioMed research international · 2015Article
- Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways.BMC complementary and alternative medicine · 2014Article
- Apoptosis and necrosis of human breast cancer cells by an aqueous extract of garden cress (Lepidium sativum) seeds.Saudi journal of biological sciences · 2013Article
- Lipid-soluble ginseng extract induces apoptosis and G0/G1 cell cycle arrest in NCI-H460 human lung cancer cells.Plant foods for human nutrition (Dordrecht, Netherlands) · 2011Article
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Authors and funding
5 authors.
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Abstract
The present study was carried out to evaluate the effects of the water extract of Chinese medicine "Pingliu Keli" (PK) on human glioma cell viability and apoptosis and to investigate its mechanisms of action in SHG-44 cells. MTT assay showed that PK had a strong cytotoxic effect on SHG-44 cells. The number of live cells was less than 20% after exposure to 90 μg/mL PK for 24 h. PK increased cytotoxicity of SHG-44 cells in a dose-dependent manner. PK caused arrest of SHG-44 cells in G1 phase at low concentration and in G2 phase at high concentration. The percentage of apoptotic cells by flow cytometric analysis of the DNA-stained cells increased to 38% and 52% after treatment with 72 and 108 μg/mL PK, respectively. In addition, PK increased the expression of proapoptotic protein (Bax) and decreased antiapoptotic protein (Bcl-2), with a concomitant increase in the levels of cleaved caspase-3, cleaved caspase-9 and cleaved poly-ADP-ribose polymerase (PARP). These results suggest that PK has a significant apoptosis inducing effect on SHG-44 glioma cells in vitro and caspase-3 may act as a potential mediator in the process.
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