ArticleEvidence-based complementary and alternative medicine : eCAM2011
Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 75 citations in OpenAlex.
- Antibacterial and anticancer properties of Solanum mauritianum fruit components analyzed using LC-QTOF-MS/MS.Scientific reports · 2025Article
- Performance, blood and antioxidant status in dual-purpose laying hens supplemented with aqueous extract of Christ's thorn jujube (Ziziphus spina-christi L.) leaves as phytogenic agent in subtropical conditions.Animal bioscience · 2024Article
- Dietary Polyphenols: Review on Chemistry/Sources, Bioavailability/Metabolism, Antioxidant Effects, and Their Role in Disease Management.Antioxidants (Basel, Switzerland) · 2024Review
- Standardization and Pharmacological Evaluation ofAnti-inflammatory & anti-allergy agents in medicinal chemistry · 2024Article
- Morphological characterization and interspecific variation among five species of Ziziphus genus to select superiors in Iran.BMC plant biology · 2023Article
- Exploring the potentials ofHeliyon · 2023Article
- Indian jujube a potential fruit tree to improve the livelihood.Saudi journal of biological sciences · 2023Review
- Article
- Assessment of genetic diversity and population structure in wild Ziziphus species from northwest India using SSR marker technique.Journal, genetic engineering & biotechnology · 2023Article
- Selection of superior genotypes of Indian jujube (Food science & nutrition · 2022Article
- Genus Ziziphus for the treatment of chronic inflammatory diseases.Saudi journal of biological sciences · 2021Review
- Article
- Integration of medicinal plants into the traditional system of medicine for the treatment of cancer in Sokoto State, Nigeria.Heliyon · 2020Article
- Phytochemicals and Medicinal Properties of Indigenous Tropical Fruits with Potential for Commercial Development.Evidence-based complementary and alternative medicine : eCAM · 2016Review
- Apoptosis-inducing effects of jujube (Zǎo) seed extracts on human Jurkat leukemia T cells.Chinese medicine · 2016Article
- Effects of curine in HL-60 leukemic cells: cell cycle arrest and apoptosis induction.Journal of natural medicines · 2015Article
- Antitumor activity of ethanolic extract of Dendrobium formosum in T-cell lymphoma: an in vitro and in vivo study.BioMed research international · 2014Article
- Anti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ziziphus mauritiana (Lamk.) is a fruit tree that has folkloric implications against many ailments and diseases. In the present study, anticancer potential of seed extract of Ziziphus mauritiana in vitro against different cell lines (HL-60, Molt-4, HeLa, and normal cell line HGF) by MTT assay as well as in vivo against Ehrich ascites carcinoma bearing Swiss albino mice was investigated. The extract was found to markedly inhibit the proliferation of HL-60 cells. Annexin and PI binding of treated HL-60 cells indicated apoptosis induction by extract in a dose-dependent manner. The cell cycle analysis revealed a prominent increase in sub Go population at concentration of 20 μg/ml and above. Agarose gel electrophoresis confirmed DNA fragmentation in HL-60 cells after 3 h incubation with extract. The extract also exhibited potent anticancer potential in vivo. Treatment of Ehrlich ascites carcinoma bearing Swiss albino mice with varied doses (100-800 mg/kg b.wt.) of plant extract significantly reduced tumor volume and viable tumor cell count and improved haemoglobin content, RBC count, mean survival time, tumor inhibition, and percentage life span. The enhanced antioxidant status in extract-treated animals was evident from decline in levels of lipid peroxidation and increased levels of glutathione, catalase, and superoxide dismutase.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.