ArticleEvidence-based complementary and alternative medicine : eCAM2011
Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Juglans regiaJournal of tropical medicine · 2025Article
- Article
- Ischemia-Reperfusion under Hyperthermia Increases Heme Oxygenase-1 in Pyramidal Neurons and Astrocytes with Accelerating Neuronal Loss in Gerbil Hippocampus.International journal of molecular sciences · 2021Article
- Therapeutic effects of liver soothing pingchuan formula decoction on experimental asthma in BALB/c mice via regulation of nerve growth factor-tyrosine kinase A pathway.Molecular medicine reports · 2018Article
- Jinkui Shenqi Pills Ameliorate Asthma with "Kidney Yang Deficiency" by Enhancing the Function of the Hypothalamic-Pituitary-Adrenal Axis to Regulate T Helper 1/2 Imbalance.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Effects of the combined extracts of Herba Epimedii and Fructus Ligustrilucidi on airway remodeling in the asthmatic rats with the treatment of budesonide.BMC complementary and alternative medicine · 2017Article
- News from Tartary: an ethnopharmacological approach to drug and therapeutic discovery.British journal of clinical pharmacology · 2017Review
- Heme oxygenase-1 inhibits basophil maturation and activation but promotes its apoptosis in T helper type 2-mediated allergic airway inflammation.Immunology · 2016Article
- Investigation of anti-asthmatic potential of dried fruits of Vitis vinifera L. in animal model of bronchial asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2016Article
- Pingchuan formula improves asthma via restoration of the Th17/Treg balance in a mouse model.BMC complementary and alternative medicine · 2015Article
- Identification of plasma protein markers common to patients with malignant tumour and Abnormal Savda in Uighur medicine: a prospective clinical study.BMC complementary and alternative medicine · 2015Article
- Cytoprotective role of heme oxygenase-1 in liver ischemia reperfusion injury.International journal of clinical and experimental medicine · 2015Review
- Effect of low-level laser therapy on allergic asthma in rats.Lasers in medical science · 2014Article
- Inhibitory effect of sihuangxiechai decoction on ovalbumin-induced airway inflammation in Guinea pigs.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Puerarin attenuates ovalbumin-induced lung inflammation and hemostatic unbalance in rat asthma model.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury.World journal of hepatology · 2013Review
- Establishment and comparison of combining disease and syndrome model of asthma with "kidney yang deficiency" and "abnormal savda".Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Involvement of Heme Oxygenase-1 Participates in Anti-Inflammatory and Analgesic Effects of Aqueous Extract of Hibiscus taiwanensis.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- The Immunomodulatory Effect of You-Gui-Wan on Dermatogoides-pteronyssinus-Induced Asthma.Evidence-based complementary and alternative medicine : eCAM · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ravan Napas (RN) is a traditional formula used to treat pulmonary symptoms and diseases such as coughing, breathing difficulty, and asthma in traditional Uighur medicine. The purpose of this study was to investigate the anti-inflammatory, and immuno-modulatory activity of RN in a well-characterized animal model of allergic asthma. Rats were sensitized with intraperitoneal (ip) ovalbumin (OVA) and alum, and then challenged with OVA aerosols. The asthma model rats were treated with RN; saline- and dexamethasone- (DXM-) treated rats served as normal and model controls. The bronchoalveolar lavage fluid (BALF) cellular differential and the concentrations of sICAM-1, IL-4, IL-5, TNF-α, INF-γ, and IgE in serum were measured. Lung sections underwent histological analysis. The immunohistochemistry S-P method was used to measure the expression of ICAM-1 and HO-1 in the lung. RN significantly reduced the number of inflammatory cells in BALF and lung tissues, decreased sICAM-1, IL-4, IL-5, TNF-α, and IgE in serum, and increased serum INF-γ. There was a marked suppression of ICAM-1 and HO-1 expression in the lung. Our results suggest that RN may have an anti-inflammatory and immuneregulatory effect on allergic bronchial asthma by modulating the balance between Th1/Th2 cytokines.
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Registered trials
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