ArticleEvidence-based complementary and alternative medicine : eCAM2011
Selective Th2 Upregulation by Crocus sativus: A Neutraceutical Spice.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect ofNutrients · 2021Pooled it
- Polyphenols in Inner Ear Neurobiology, Health and Disease: From Bench to Clinics.Medicina (Kaunas, Lithuania) · 2023Review
- Effects of saffron and its active constituent crocin on cancer management: A narrative review.Longhua Chinese medicine · 2022Article
- Saffron: A potential drug-supplement for severe acute respiratory syndrome coronavirus (COVID) management.Heliyon · 2021Review
- Bioanalytical Method Development and Validation Study of Neuroprotective Extract of Kashmiri Saffron Using Ultra-Fast Liquid Chromatography-Tandem Mass Spectrometry (UFLC-MS/MS): In Vivo Pharmacokinetics of Apocarotenoids and Carotenoids.Molecules (Basel, Switzerland) · 2021Article
- Effects of saffron (Crocus sativus) petal ethanolic extract on hematology, antibody response, and spleen histology in rats.Avicenna journal of phytomedicine · 2014Article
- Evaluation of a Unani polyherbal formulation (Tiryaqe wabai) as an immunostimulator in elderly persons.Ancient science of life · 2013Article
- Dietary Crocin Inhibits Colitis and Colitis-Associated Colorectal Carcinogenesis in Male ICR Mice.Evidence-based complementary and alternative medicine : eCAM · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immunomodulatory activity of an Indian neutraceutical spice, saffron (Crocus sativus) was studied on Th(1) and Th(2) limbs of the immune system. Oral administration of alcoholic extract of Crocus sativus (ACS) at graded dose levels from 1.56-50 mg/kg p.o. potentiated the Th(2) response of humoral immunity causing the significant increases in agglutinating antibody titre in mice at a dose of 6.25 mg/kg and an elevation of CD19(+) B cells and IL-4 cytokine, a signature cytokine of Th(2) pathway. Appreciable elevation in levels of IgG-1 and IgM antibodies of the primary and secondary immune response was observed. However, ACS showed no appreciable expression of the Th(1) cytokines IL-2 (growth factor for CD4(+) T cells) and IFN-γ (signature cytokine of Th(1) response). A significant modulation of immune reactivity was observed in all the animal models used. This paper represents the selective upregulation of the Th(2) response of the test material and suggests its use for subsequent selective Th(2) immunomodulation.
Identifiers
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Registered trials
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