ArticleInternational journal of Alzheimer's disease2010
Gene-environment interaction research and transgenic mouse models of Alzheimer's disease.
Article in International journal of Alzheimer's disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Associations between physical activity and cognitive dysfunction in older companion dogs: results from the Dog Aging Project.GeroScience · 2023Observational
- The Role of the Thioredoxin System in Brain Diseases.Antioxidants (Basel, Switzerland) · 2022Review
- Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models.Neurobiology of disease · 2021Review
- Early Life Stress and Epigenetics in Late-onset Alzheimer's Dementia: A Systematic Review.Current genomics · 2018Review
- Alzheimer's Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits.Frontiers in neuroscience · 2018Review
- The epigenetics of aging and neurodegeneration.Progress in neurobiology · 2015Review
- Integrative Transcriptome Profiling of Cognitive Aging and Its Preservation through Ser/Thr Protein Phosphatase Regulation.PloS one · 2015Article
- Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.Molecular neurodegeneration · 2014Review
- Epigenetic modifications of chronic hypoxia-mediated neurodegeneration in Alzheimer's disease.Translational neurodegeneration · 2014Article
- Epigenetic mechanisms in Alzheimer's disease.Degenerative neurological and neuromuscular disease · 2014Article
- Current concepts in Alzheimer's Disease: molecules, models and translational perspectives.Molecular neurodegeneration · 2013Review
- Histone deacetylase 2 in the mouse hippocampus: attenuation of age-related increase by caloric restriction.Current Alzheimer research · 2013Article
- Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.Neurobiology of aging · 2013Article
- Gene-environment interaction in Alzheimer's disease.American journal of Alzheimer's disease and other dementias · 2012Article
- Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction.Neurobiology of aging · 2012Article
- Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction.Current Alzheimer research · 2012Article
- Cognitive reserve, cortical plasticity and resistance to Alzheimer's disease.Alzheimer's research & therapy · 2012Article
- Methylmercury: a potential environmental risk factor contributing to epileptogenesis.Neurotoxicology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 3 countries.
Funding
Abstract
The etiology of the sporadic form of Alzheimer's disease (AD) remains largely unknown. Recent evidence has suggested that gene-environment interactions (GxE) may play a crucial role in its development and progression. Whereas various susceptibility loci have been identified, like the apolipoprotein E4 allele, these cannot fully explain the increasing prevalence of AD observed with aging. In addition to such genetic risk factors, various environmental factors have been proposed to alter the risk of developing AD as well as to affect the rate of cognitive decline in AD patients. Nevertheless, aside from the independent effects of genetic and environmental risk factors, their synergistic participation in increasing the risk of developing AD has been sparsely investigated, even though evidence points towards such a direction. Advances in the genetic manipulation of mice, modeling various aspects of the AD pathology, have provided an excellent tool to dissect the effects of genes, environment, and their interactions. In this paper we present several environmental factors implicated in the etiology of AD that have been tested in transgenic animal models of the disease. The focus lies on the concept of GxE and its importance in a multifactorial disease like AD. Additionally, possible mediating mechanisms and future challenges are discussed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.