Evidence map›Paper›PMID 20953351›Full record

ArticleFuture neurology2010

Inter-relationships among behavioral markers, genes, brain and treatment in dyslexia and dysgraphia.

Virginia Berninger, Todd Richards

Open access · greenAbstract read
In one paragraph

Article in Future neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 84 citations in OpenAlex.

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  7. Review
  8. Why Children With Dyslexia Struggle With Writing and How to Help Them.Language, speech, and hearing services in schools · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Virginia BerningerDepartment of Educational Psychology, 322 Miller, Box 353600, University of Washington, Seattle, WA 98195-3600, USA.
Todd Richards
University of Washington · US

Funding

TRAINING TEACHERS ABOUT READING AND WRITING INTERVENTIONS--EFFECTIVENESS STUDYP50HD033812 · NICHD · UNIVERSITY OF WASHINGTON · PI BERNINGER, VIRGINIA WISE · 1996 to 2005
$9.1M
INTERVENTIONS FOR COMPONENT WRITING DISABILITIESR01HD025858 · NICHD · UNIVERSITY OF WASHINGTON · PI BERNINGER, VIRGINIA WISE · 1989 to 2005
$3.2M
INTERVENTIONS FOR COMPONENT WRITING DISABILITIESR55HD025858 · NICHD · UNIVERSITY OF WASHINGTON · PI BERNINGER, VIRGINIA W · 1992 to 1994
–
NICHD NIH HHS P50 HD033812NICHD NIH HHS R01 HD025858
6 · The paper itself

Abstract

Cross-country, longitudinal twin studies provide strong evidence for both the biological and environmental basis of dyslexia, and the stability of genetic influences on reading and spelling, even when skills improve in response to instruction. Although DNA studies aimed at identifying gene candidates in dyslexia and related phenotypes (behavioral expression of underlying genotypes); and imaging studies of brain differences between individuals with and without dyslexia and the brain's response to instructional treatment are increasing, this review illustrates, with the findings of one multidisciplinary research center, an emerging trend to investigate the inter-relationships among genetic, brain and instructional treatment findings in the same sample, which are interpreted in reference to a working-memory architecture, for dyslexia (impaired decoding and spelling) and/or dysgraphia (impaired handwriting). General principles for diagnosis and treatment, based on research with children who failed to respond to the regular instructional program, are summarized for children meeting research criteria for having or being at risk for dyslexia or dysgraphia. Research documenting earlier emerging specific oral language impairment during preschool years associated with reading and writing disabilities during school years is also reviewed. Recent seminal advances and projected future trends are discussed for linking brain endophenotypes and gene candidates, identifying transchromosomal interactions, and exploring epigenetics (chemic al modifications of gene expression in response to developmental or environmental changes). Rather than providing final answers, this review highlights past, current and emerging issues in dyslexia research and practice.

Identifiers

PMID20953351
PMCPMC2953808
OpenAlexW2143068011

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.