ArticleMediators of inflammation2010
12/15-lipoxygenase is an interleukin-13 and interferon-γ counterregulated-mediator of allergic airway inflammation.
Article in Mediators of inflammation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Crafting Molecular Tools for 15-Lipoxygenase-1 in a Single Step.Angewandte Chemie (International ed. in English) · 2025Article
- Hematopoietic 12/15-lipoxygenase activity negatively contributes to fungal-associated allergic asthma.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- A review on the relationship between Arachidonic acid 15-Lipoxygenase (ALOX15) and diabetes mellitus.PeerJ · 2023Review
- Comparison of Overall Immunity Levels among Workers at Grape Orchard, Rose Greenhouse, and Open-Field Onion Farm.Safety and health at work · 2022Article
- Type-2 airway inflammation in mild asthma patients with high blood eosinophils and high fractional exhaled nitric oxide.Clinical and translational science · 2021Observational
- Regulation of Tissue Inflammation by 12-Lipoxygenases.Biomolecules · 2021Review
- Predictive significance of arachidonate 15-lipoxygenase for eosinophilic chronic rhinosinusitis with nasal polyps.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020Article
- Up-regulation of 15-lipoxygenase enzymes and products in functional and non-functional pituitary adenomas.Lipids in health and disease · 2019Article
- Altered immune responses in broiler chicken husbandry workers and their association with endotoxin exposure.Industrial health · 2018Article
- The nasal methylome and childhood atopic asthma.The Journal of allergy and clinical immunology · 2017Article
- Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties.European journal of medicinal chemistry · 2016Article
- Activity-Based Probes for 15-Lipoxygenase-1.Angewandte Chemie (International ed. in English) · 2016Article
- Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.Journal of medicinal chemistry · 2015Article
- Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.Genes, chromosomes & cancer · 2013Article
- Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Impact of adiponectin overexpression on allergic airways responses in mice.Journal of allergy · 2013Article
- Dendritic cells and alveolar macrophages mediate IL-13-induced airway inflammation and chemokine production.The Journal of allergy and clinical immunology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Interleukin-13 and interferon-γ are important effectors of T-helper cells. Interleukin-13 increases expression of the arachidonic acid-metabolizing enzyme, 15-lipoxygenase-1, in a variety of cell types. 15-lipoxygenase-1 is dramatically elevated in the airways of subjects with asthma. Studies in animals indicate that 15-lipoxygenase-1 contributes to the development of allergic airway inflammation but is protective in some other forms of inflammation. We tested the hypothesis that the ability of interleukin-13 and interferon-γ to counterregulate allergic airway inflammation was potentially mediated by counterregulation of 12/15-lipoxygenase, the mouse ortholog of 15-lipoxygenase-1. The airways of mice were treated with interleukin-13 or interferon-γ one day prior to each of the four allergen exposures. Interleukin-13 augmented and interferon-γ inhibited allergic airway inflammation independently of systemic IgE and mucosal IgA responses but in association with counterregulation of 12/15-lipoxygenase. Interleukin-13 and interferon-γ counterregulate 12/15-lipoxygenase potentially contributing to the effects of these cytokines on allergic airway inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.