ArticleSoft matter2010
Nanoscopic mechanical anisotropy in hydrogel surfaces.
Article in Soft matter, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
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Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- Binary fabrication of decellularized lung extracellular matrix hybridgels for in vitro chronic obstructive pulmonary disease modeling.Acta biomaterialia · 2024Article
- The effects of surface topography modification on hydrogel properties.APL bioengineering · 2021Review
- Determination by Relaxation Tests of the Mechanical Properties of Soft Polyacrylamide Gels Made for Mechanobiology Studies.Polymers · 2021Article
- Lyophilized Polyvinylpyrrolidone Hydrogel for Culture of Human Oral Mucosa Stem Cells.Materials (Basel, Switzerland) · 2021Article
- Photo-tunable hydrogel mechanical heterogeneity informed by predictive transport kinetics model.Soft matter · 2020Article
- High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy.Nature communications · 2018Article
- Effects of Liposomes Contained in Thermosensitive Hydrogels as Biomaterials Useful in Neural Tissue Engineering.Materials (Basel, Switzerland) · 2017Article
- Platelets stored at 4°C contribute to superior clot properties compared to current standard-of-care through fibrin-crosslinking.British journal of haematology · 2017Article
- Nano-rheology of hydrogels using direct drive force modulation atomic force microscopy.Soft matter · 2015Article
- Decoupling the role of stiffness from other hydroxyapatite signalling cues in periosteal derived stem cell differentiation.Scientific reports · 2015Article
- Surface Properties of Nanostructured Bio-Active Interfaces: Impacts of Surface Stiffness and Topography on Cell-Surface Interactions.RSC advances · 2013Article
- Dynamic and reversible surface topography influences cell morphology.Journal of biomedical materials research. Part A · 2013Article
- The alignment and fusion assembly of adipose-derived stem cells on mechanically patterned matrices.Biomaterials · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The bulk mechanical properties of soft materials have been studied widely, but it is unclear to what extent macroscopic behavior is reflected in nanomechanics. Using an atomic force microscopy (AFM) imaging method called force spectroscopy mapping (FSM), it is possible to map the nanoscopic spatial distribution of Young's modulus, i.e. "stiffness," and determine if soft or stiff polymer domains exist to correlate nano- and macro-mechanics. Two model hydrogel systems typically used in cell culture and polymerized by a free radical polymerization process, i.e. poly (vinyl pyrrolidone) (PVP) and poly(acrylamide) (PAam) hydrogels, were found to have significantly different nanomechanical behavior despite relatively similar bulk stiffness and roughness. PVP gels contained a large number of soft and stiff nanodomains, and their size was inversely related to crosslinking density and changes in crosslinking efficiency within the hydrogel. In contrast, PAam gels displayed small nanodomains occuring at low frequency, indicating relatively uniform polymerization. Given the responsiveness of cells to changes in gel stiffness, inhomogeneities found in the PVP network indicate that careful nanomechanical characterization of polymer substrates is necessary to appreciate complex cell behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.