ArticleNature genetics2010
Association analyses identify six new psoriasis susceptibility loci in the Chinese population.
Article in Nature genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 16 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
156 citing papers in PubMed, 16 syntheses or guidelines pooled it, 315 citations in OpenAlex.
- Systemic Treatment Strategies for Patients with Psoriasis and Psoriatic Arthritis in the Setting of ANA Positivity or Lupus Spectrum Disease: A Comprehensive Systematic Review.International journal of molecular sciences · 2026Pooled it
- A resource for integrated genomic analysis of the human liver.Scientific reports · 2022Pooled it
- Genetic variant inAnnals of medicine · 2021Pooled it
- Associations betweenBioMed research international · 2021Pooled it
- Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants.Nature communications · 2017Pooled it
- Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.American journal of human genetics · 2015Pooled it
- Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci.Nature communications · 2015Pooled it
- Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.Nature communications · 2015Pooled it
- Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population.Arthritis research & therapy · 2015Pooled it
- Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations.European journal of human genetics : EJHG · 2013Pooled it
- Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.Nature genetics · 2013Pooled it
- Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.Nature genetics · 2012Pooled it
- Association of IL23R polymorphisms with psoriasis and psoriatic arthritis: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Pooled it
- Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis.American journal of human genetics · 2012Pooled it
- Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.American journal of human genetics · 2012Pooled it
- TNFAIP3 gene polymorphisms are associated with response to TNF blockade in psoriasis.The Journal of investigative dermatology · 2012Pooled it
- Trial
- Immunogenetics in psoriasis: towards personalised diagnosis and treatment strategies.Genes and immunity · 2026Review
- Synthetic Curcuminoids Combined with Blue-Light-Mediated Photodynamic Therapy for Anti-Inflammatory Effect and Potential Mechanism on Imiquimod-Induced Psoriasis-like Proliferation of Keratinocytes.International journal of molecular sciences · 2026Article
- Associations of plasma proteomic and polygenic profiling with incident psoriasis risk: a prospective cohort study.Journal of global health · 2026Article
96 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
67 authors at 14 institutions in 3 countries.
Funding
Abstract
We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10⁻⁸) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10⁻²¹) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 × 10⁻³ and P = 7.9 × 10⁻³, respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 × 10⁻³ and P = 1.5 × 10⁻³, respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.