ArticleIndian journal of ophthalmology
Targeting CYP450 modulation to decrease the risk of induced cataract in the experimental model.
Article in Indian journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Exploring Causal Relationships Between Kidney Function and the Risk of Senile Cataract and Primary Open-Angle Glaucoma: A Mendelian Randomization Study and Bioinformatics Analyses.Journal of multidisciplinary healthcare · 2025Article
- Oxidative Stress in Cataract Formation: Is There a Treatment Approach on the Horizon?Antioxidants (Basel, Switzerland) · 2024Review
- Role of Cytochrome Modulators in Altering the Occurrence of Cataract in Rats.Journal of clinical and diagnostic research : JCDR · 2015Article
- A simple and stable galactosemic cataract model for rats.International journal of clinical and experimental medicine · 2015Article
- Effect of rifampicin and erythromycin on the initiation of galactose induced cataract in rats.Journal of pharmacology & pharmacotherapeutics · 2012Article
- Inferences from targeting CYP450 modulation to decrease the risk of induced cataract in the experimental model?Indian journal of ophthalmologyArticle
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes is one of the major causes of cataract. Some drugs prescribed for the treatment of diabetes are the modulators of CYP450, which may alter the risk of cataract.
objectiveTo study the effect of CYP450 modulation in galactosemic cataract. MATERIALS AND
methodsMale Sprague-Dawley suckling rats were allotted to four groups (n = 6), as follows: Group 1: Normal control, Group 2: Galactose control, Group 3: CYP450 inhibitor pretreated and Group 4: CYP450 inducer pretreated. Cataract was induced in animals of all groups except group 1 by feeding them galactose (50%), 21 days after parturition. From the eighteenth day of life, CYP450 inhibitor (nifedipine; 8.1 mg/kg) and CYP450 inducer (pioglitazone; 3.8 mg/kg) were given orally to groups 3 and 4, respectively. The maturation pattern of the cataract was observed by an operating microscope, every third day. Biochemical changes in the lenses of all groups, for example, CYP450 activity expressed as ΅M NADPH oxidized / unit time, alterations in the levels of total proteins, soluble proteins, and reduced glutathione (GSH) following the induction of cataract, were estimated.
resultsThe microscopic examination of the lenses indicated that CYP450 inhibitor pre-treatment delayed (fourteenth day) the occurrence of cataract, while CYP450 inducer pretreatment demonstrated an early (ninth day) cataract as compared to galactose control rats (twelfth day). A significant decrease and increase in CYP450 activity was observed with the CYP450 inhibitor and inducer pre-treatment, respectively. There was no alteration in the GSH level, but a significant increase in total and soluble protein was found in groups 3 and 4 as compared to group 2.
conclusionCYP450 may have a role in the initiation of cataract without any effect on the maturation pattern, as revealed by the delayed occurrence of cataract with the CYP450 inhibitor and an early onset of cataract with the CYP450 inducer.
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