ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Circadian regulation of cardiovascular function: a role for vasoactive intestinal peptide.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- Exercise and Circadian Rhythm Regulation: Mechanisms, Resilience, and Therapeutic Potential for Neurological Diseases.CNS neuroscience & therapeutics · 2026Review
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- Chronic mistimed feeding results in renal fibrosis and disrupted circadian blood pressure rhythms.American journal of physiology. Renal physiology · 2024Article
- Multiple time points of transcriptome analysis revealed altered genes involved in maintaining hibernation in the hypothalamus ofFrontiers in neuroscience · 2024Article
- The Circadian Biology of Heart Failure.Circulation research · 2023Review
- Timing of food intake in mice unmasks a role for the cardiomyocyte circadian clock mechanism in limiting QT-interval prolongation.Chronobiology international · 2022Article
- Dissecting the Roles of the Autonomic Nervous System and Physical Activity on Circadian Heart Rate Fluctuations in Mice.Frontiers in physiology · 2021Article
- The Circadian Clock Is Sustained in the Thyroid Gland of VIP Receptor 2 Deficient Mice.Frontiers in endocrinology · 2021Article
- The circadian system modulates the rate of recovery of systolic blood pressure after exercise in humans.Sleep · 2020Article
- A time to fight: Circadian control of aggression and associated autonomic support.Autonomic neuroscience : basic & clinical · 2019Review
- Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms.Heart rhythm · 2019Review
- Misalignment with the external light environment drives metabolic and cardiac dysfunction.Nature communications · 2017Article
- Drosophila DH31 Neuropeptide and PDF Receptor Regulate Night-Onset Temperature Preference.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Collective timekeeping among cells of the master circadian clock.The Journal of endocrinology · 2016Review
- In synch but not in step: Circadian clock circuits regulating plasticity in daily rhythms.Neuroscience · 2016Review
- How the Body Talks to the Brain; Peripheral Mediators of Physical Activity-Induced Proliferation in the Adult Hippocampus.Brain plasticity (Amsterdam, Netherlands) · 2015Review
- Constant light enhances synchrony among circadian clock cells and promotes behavioral rhythms in VPAC2-signaling deficient mice.Scientific reports · 2015Article
- A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention.American journal of physiology. Renal physiology · 2013Article
- The clock shop: coupled circadian oscillators.Experimental neurology · 2013Review
- Voluntary scheduled exercise alters diurnal rhythms of behaviour, physiology and gene expression in wild-type and vasoactive intestinal peptide-deficient mice.The Journal of physiology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The circadian system, driven by the suprachiasmatic nucleus (SCN), regulates properties of cardiovascular function. The dysfunction of this timing system can result in cardiac pathology. The neuropeptide vasoactive intestinal peptide (VIP) is crucial for circadian rhythms in a number of biological processes including SCN electrical activity and wheel running behavior. Anatomic evidence indicates that SCN neurons expressing VIP are well positioned to drive circadian regulation of cardiac function through interactions with the autonomic centers. In this study, we tested the hypothesis that loss of VIP would result in circadian deficits in heart rate (HR) and clock gene expression in cardiac tissue. We implanted radiotelemetry devices into VIP-deficient mice and wild-type (WT) controls and continuously recorded HR, body temperature, and cage activity in freely moving mice. Under light-dark conditions, VIP-deficient mice displayed weak rhythms in HR, body temperature, and cage activity, with onsets that were advanced in phase compared with WT mice. Similarly, clock gene expression in cardiac tissue was rhythmic but phase advanced in mutant mice. In constant darkness, the normal circadian rhythms in HR were lost in VIP-deficient mice; however, most mutant mice continued to exhibit circadian rhythms of body temperature with shortened free-running period. The loss of VIP altered, but did not abolish, autonomic regulation of HR. Analysis of the echocardiograms did not find any evidence for a loss of cardiac function in VIP-deficient mice, and the size of the hearts did not differ between genotypes. These results demonstrate that VIP is an important regulator of physiological circadian rhythmicity in the heart.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.