ReviewCardiovascular research2011
The potential role of the red blood cell in nitrite-dependent regulation of blood flow.
Review in Cardiovascular research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Glutathione-Triggered Nitrite Release From Organic Nitrites Enhances Nitric Oxide Bioavailability in Mammalian Cells.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Plasma-Activated Water (PAW) Decontamination of Foodborne Bacteria in Shucked Oyster Meats Using a Compact Flow-Through Generator.Foods (Basel, Switzerland) · 2025Article
- Increased Anion Exchanger-1 (Band 3) on the Red Blood Cell Membrane Accelerates Scavenging of Nitric Oxide Metabolites and Predisposes Hypertension Risks.Function (Oxford, England) · 2025Article
- Erythroid anion transport, nitric oxide, and blood pressure.Frontiers in physiology · 2024Article
- Potential role for age as a modulator of oral nitrate reductase activity.Nitric oxide : biology and chemistry · 2021Article
- Nitrite and nitrate chemical biology and signalling.British journal of pharmacology · 2019Review
- The dichotomous role of HBiochemical pharmacology · 2018Review
- A mathematical model for the role of NNitric oxide : biology and chemistry · 2016Article
- Hemoglobin Effects on Nitric Oxide Mediated Hypoxic Vasodilation.Advances in experimental medicine and biology · 2016Article
- Article
- Mechanisms of human erythrocytic bioactivation of nitrite.The Journal of biological chemistry · 2015Article
- Microfluidic device with tunable post arrays and integrated electrodes for studying cellular release.The Analyst · 2014Article
- Mechanisms of nitrite bioactivation.Nitric oxide : biology and chemistry · 2014Review
- Protein kinase C delta modulates endothelial nitric oxide synthase after cardiac arrest.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- Endothelial nitric oxide synthase in red blood cells: key to a new erythrocrine function?Redox biology · 2014Review
- Effects of erythrocyte aging on nitric oxide and nitrite metabolism.Antioxidants & redox signaling · 2013Article
- Hemoglobin-mediated nitric oxide signaling.Free radical biology & medicine · 2013Review
- Is methemoglobin an inert bystander, biomarker or a mediator of oxidative stress--The example of anemia?Redox biology · 2013Review
- Article
- Role of the b93cys, ATP and adenosine in red cell dependent hypoxic vasorelaxation.International journal of physiology, pathophysiology and pharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Nitrite was once thought to have little physiological relevance. However, nitrite is now being increasingly recognized as a therapeutic or possibly even physiological precursor of nitric oxide (NO) that is utilized when needed to increase blood flow. It is likely that different mechanisms for nitrite bioconversion occur in different tissues, but in the vascular system, there is evidence that erythrocyte haemoglobin (Hb) is responsible for the oxygen-dependent reduction of nitrite to modulate blood flow. Here, we review the complex chemical interactions of Hb and nitrite and discuss evidence supporting its role in vasodilation. We also discuss ongoing work focused on defining the precise mechanisms for export of NO activity from red blood cells and of other pathways that may mediate nitrite-dependent vasodilation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.