ArticleNucleic acids research2011
CancerResource: a comprehensive database of cancer-relevant proteins and compound interactions supported by experimental knowledge.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Computational resources associating diseases with genotypes, phenotypes and exposures.Briefings in bioinformatics · 2019Pooled it
- Gene Network Rewiring to Study Melanoma Stage Progression and Elements Essential for Driving Melanoma.PloS one · 2015Pooled it
- Drug repositioning discovery for early- and late-stage non-small-cell lung cancer.BioMed research international · 2014Pooled it
- Review
- CellMiner Cross-Database (CellMinerCDB) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics.Nucleic acids research · 2021Article
- In silico design of novel proton-pump inhibitors with reduced adverse effects.Frontiers of medicine · 2019Article
- Attractor - a new turning point in drug discovery.Drug design, development and therapy · 2019Review
- A review of connectivity map and computational approaches in pharmacogenomics.Briefings in bioinformatics · 2018Review
- Unearthing new genomic markers of drug response by improved measurement of discriminative power.BMC medical genomics · 2018Article
- Precision and recall oncology: combining multiple gene mutations for improved identification of drug-sensitive tumours.Oncotarget · 2017Article
- NPCARE: database of natural products and fractional extracts for cancer regulation.Journal of cheminformatics · 2017Article
- CancerResource--updated database of cancer-relevant proteins, mutations and interacting drugs.Nucleic acids research · 2016Article
- Systematic assessment of multi-gene predictors of pan-cancer cell line sensitivity to drugs exploiting gene expression data.F1000Research · 2016Article
- The Mutational Landscape of the Oncogenic MZF1 SCAN Domain in Cancer.Frontiers in molecular biosciences · 2016Article
- Mining featured micro ribonucleic acids associated with lung cancer based on bioinformatics.Thoracic cancer · 2015Article
- Integrative network-based approach identifies key genetic elements in breast invasive carcinoma.BMC genomics · 2015Article
- Human cancer databases (review).Oncology reports · 2015Review
- Article
- TaxKB: a knowledge base for new taxane-related drug discovery.BioData mining · 2015Article
- Phytochemica: a platform to explore phytochemicals of medicinal plants.Database : the journal of biological databases and curation · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the development of methods for cancer diagnosis and treatment, a vast amount of information is generated. Novel cancer target proteins have been identified and many compounds that activate or inhibit cancer-relevant target genes have been developed. This knowledge is based on an immense number of experimentally validated compound-target interactions in the literature, and excerpts from literature text mining are spread over numerous data sources. Our own analysis shows that the overlap between important existing repositories such as Comparative Toxicogenomics Database (CTD), Therapeutic Target Database (TTD), Pharmacogenomics Knowledge Base (PharmGKB) and DrugBank as well as between our own literature mining for cancer-annotated entries is surprisingly small. In order to provide an easy overview of interaction data, it is essential to integrate this information into a single, comprehensive data repository. Here, we present CancerResource, a database that integrates cancer-relevant relationships of compounds and targets from (i) our own literature mining and (ii) external resources complemented with (iii) essential experimental and supporting information on genes and cellular effects. In order to facilitate an overview of existing and supporting information, a series of novel information connections have been established. CancerResource addresses the spectrum of research on compound-target interactions in natural sciences as well as in individualized medicine; CancerResource is available at: http://bioinformatics.charite.de/cancerresource/.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.